COVID-19 nephropathy: probable mechanisms of kidney failure

Aya Khouchlaa; Abdelhakim Bouyahya

doi:10.34172/jnp.2020.35

J Nephropathol. 2020;9(4): e35.
doi: 10.34172/jnp.2020.35

Scopus ID: 85085333488

Abstract View: 2868

PDF Download: 1599

Epidemiology and Prevention

COVID-19 nephropathy: probable mechanisms of kidney failure

Aya Khouchlaa ¹^* , Abdelhakim Bouyahya ¹

¹ Department of Biology, Faculty of Science, Genomic Center of Human Pathologies, Faculty of Medicine, Laboratory of Human Pathologies Biology, Mohammed V University, Rabat, Morocco

*Corresponding Author: *Corresponding author: Aya Khouchlaa, Email: , Email: aya.khouchlaa@gmail.com

Keywords: COVID-19 nephropathy;, Coronavirus, Acute kidney injury, C5b-9 complexes, Interstitum

Implication for health policy/practice/research/medical education:

The mechanistic understanding of signaling pathways that contributes to the kidney involvement by coronavirus disease 2019 (COVID-19) is an extremely critical point for improving therapeutic options. These pathways consist of the production of pro-inflammatory factors, the infiltration of pro-inflammatory cells into the renal interstitium, the activation of C5b-9 complexes, and receptorangiotensin converting enzyme 2 (ACE2). Cytopathogenic effects and invasion into renal tubular cells have been confirmed.

Please cite this paper as: Khouchlaa A, Bouyahya A. COVID-19 nephropathy: probable mechanisms of kidney failure. J Nephropathol. 2020;9(4):e35. DOI: 10.34172/jnp.2020.35.