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J Nephropathol. 2020;9(4): e35.
doi: 10.34172/jnp.2020.35

Scopus ID: 85085333488
  Abstract View: 2885
  PDF Download: 1607

Epidemiology and Prevention

COVID-19 nephropathy: probable mechanisms of kidney failure

Aya Khouchlaa 1* ORCID logo, Abdelhakim Bouyahya 1 ORCID logo

1 Department of Biology, Faculty of Science, Genomic Center of Human Pathologies, Faculty of Medicine, Laboratory of Human Pathologies Biology, Mohammed V University, Rabat, Morocco
*Corresponding Author: *Corresponding author: Aya Khouchlaa, Email: , Email: aya.khouchlaa@gmail.com

Implication for health policy/practice/research/medical education:

The mechanistic understanding of signaling pathways that contributes to the kidney involvement by coronavirus disease 2019 (COVID-19) is an extremely critical point for improving therapeutic options. These pathways consist of the production of pro-inflammatory factors, the infiltration of pro-inflammatory cells into the renal interstitium, the activation of C5b-9 complexes, and receptorangiotensin converting enzyme 2 (ACE2). Cytopathogenic effects and invasion into renal tubular cells have been confirmed.

Please cite this paper as: Khouchlaa A, Bouyahya A. COVID-19 nephropathy: probable mechanisms of kidney failure. J Nephropathol. 2020;9(4):e35. DOI: 10.34172/jnp.2020.35.

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Submitted: 12 Apr 2020
Accepted: 16 Apr 2020
ePublished: 22 Apr 2020
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