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J Nephropathol. 2022;11(3): e15957.
doi: 10.34172/jnp.2022.15957
  Abstract View: 135
  PDF Download: 66

Case Report

Mixed cryoglobulinemia; a rare presentation of Waldenström macroglobulinemia

Catarina Isabel Ribeiro 1* ORCID logo, Clara Santos 1, Clara Almeida 1, Teresa Melo 2, David Tente 3, João Carlos Fernandes 1

1 Nephrology Department, Vila Nova de Gaia-Espinho Hospital Center, Vila Nova de Gaia, Porto, Portugal
2 Clinical Hematology Department, Vila Nova de Gaia-Espinho Hospital Center, Vila Nova de Gaia, Porto, Portugal
3 Pathologic Anatomy Department, Vila Nova de Gaia-Espinho Hospital Center, Vila Nova de Gaia, Porto, Portugal
*Corresponding Author: Corresponding author: Catarina Isabel Correia Dias Ribeiro, Email: catarina.isabel.ribeiro@gmail.com, , Email: catarina.dias.ribeiro@chvng.min-saude.pt

Abstract

Type II mixed cryoglobulinemia is a systemic disease mediated by immune complexes. Renal involvement is present in almost one third of the cases and the membranoprolifer-ative pattern is the most common histological presentation. In turn, in Waldenström macroglobulinemia, renal impairment is rare, with few cases of associated cryoglobu-linemia being reported. The authors present the case of a patient with type II mixed cry-oglobulinemia associated with Waldenström macroglobulinemia diagnosis.

Implication for health policy/practice/research/medical education:

Type II mixed cryoglobulinemia is a systemic disease mediated by immune complexes and renal involvement is present in almost one third of the cases. In turn, in Walden-ström Macroglobulinemia, renal impairment is rare, with few cases of associated cryo-globulinemia being reported. The authors present the case of a patient with type II mixed cryoglobulinemia associated with Waldenström Macroglobulinemia, and empha-size the idiosyncrasy of clinical presentation and the importance of a systematic and methodical approach in the etiological screening of cryoglobulinemia.

Please cite this paper as: Isabel Ribeiro C, Santos C, Almeida C, Melo T, Tente D, Carlos Fernandes J. Mixed cryoglobulinemia; a rare presentation of Waldenström macroglobulinemia. J Nephropathol. 2022;11(3):e15957. DOI: 10.34172/jnp.2022.15957.

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Submitted: 05 Apr 2020
Accepted: 31 Jul 2020
ePublished: 13 Aug 2020
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