J Nephropathol. 2021;10(4): e43.
doi: 10.34172/jnp.2021.43
  Abstract View: 154
  PDF Download: 91

Epidemiology and Prevention

Successful treatment of collapsing focal segmental glomerulosclerosis in a patient

Luísa Helena Pereira 1 * ORCID logo, Ana Cabrita 1, Mário Góis 2, Helena Viana 2, Sandra Sampaio 1, Pedro Leão Neves 1

1 Nephrology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal
2 Nephrology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
*Corresponding author: Luisa Helena Pereira, Email: luisahelenapereira91@gmail.com


Focal segmental glomerulosclerosis (FSGS) is a recognized cause of renal disease worldwide. The collapsing variant is distinct from the others, characterized clinically by a more severe nephrotic syndrome generally resistant to immunosuppressive therapy. It is known that a great number of patients progress to end-stage renal disease. Recognizing this lesion in biopsy is frequently challenging owing to the focal nature of the process which highlights the need for keeping a high index of suspicion for the diagnosis. We report and discuss a case of a non-HIV collapsing FSGS, followed by a complete (unexpected) renal recovery after an oral corticosteroid course.
Keywords: Focal segmental glomerulosclerosis, Collapsing variant, Renal biopsy, Corticoid treatment

Implication for health policy/practice/research/medical education: This report highlights a focal glomerulosclerosis collapsing variant diagnosis and treatment, which is of special interest considering its unexpected complete response after an oral corticosteroid course, during 19 months of follow up.

Please cite this paper as: Pereira LH, Cabrita A, Góis M, Viana H, Sampaio S, Neves PL. Successful treatment of collapsing focal segmental glomerulosclerosis in a patient. J Nephropathol. 2021;10(4):e43. DOI: 10.34172/jnp.2021.43.

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Abstract View: 154

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Submitted: 02 Oct 2020
Accepted: 29 Oct 2020
ePublished: 10 Nov 2020
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