Bhargav Patel
1 
, Mohammad Ebrahimi Kalan
2 , Maryam Khosravian
3 , Audrey Tolouian
4 , Ramin Tolouian
5 , Mahnaz Aboufazeli
6 , Masoumeh Asgharpour
7* , Amirhesam Alirezaei
8* 1 Department of Internal Medicine, University of Arizona, Tucson, AZ, USA
2 Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL, USA
3 Institute of Biology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
4 The University of Texas at El Paso School of Nursing, El Paso, Texas, USA
5 Division of Nephrology, Southern Arizona VA Healthcare System, Tucson, AZ, USA
6 Departemt of Physical Therapy Education, Western University of Health Sciences, Pomona, California, USA
7 Department of Nephrology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
8 Department of Nephrology, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Lung cancer is the leading cause of cancer deaths worldwide, accounting for an estimated 1.8 million deaths. Lung cancer is also the most common primary cancer leading to soft tissue (ST) metastasis. Renal disease may occur as a direct or indirect consequence of the cancer itself (e.g., postrenal obstruction, compression, or infiltration), its treatment (e.g., radiotherapy or chemotherapy), or its related complications (e.g., opportunistic infection). Existing evidence shows that the most frequent primary solid tumor responsible for renal metastasis is pulmonary carcinoma, followed by gastric, breast, soft tissue, and thyroid carcinomas. Chronic kidney disease is a potential risk factor in the survival of patients with lung cancer. In this review, we will discuss causes of kidney injury in relation to lung cancer, potential mechanisms of kidney injury, and treatment options.
Implication for health policy/practice/research/medical education: The most common primary solid tumor responsible for renal metastasis is pulmonary carcinoma. In this review, we showed that chronic kidney disease harmfully affects the survival of individuals with pulmonary malignancy.
Please cite this paper as: Patel B, Kalan ME, Khosravian M, Tolouian A, Tolouian R, Aboufazeli M, et al. Lung cancer and kidney injury: an updated review. J Nephropathol. 2021;10(2):e12. DOI: 10.34172/jnp.2021.12.