J Nephropathol. 2021;10(4): e37.
doi: 10.34172/jnp.2021.37
  Abstract View: 219
  PDF Download: 118


Acute kidney injury due to cytokine storm in patients with COVID-19 infection

Sepehr Ebrahimi-Dehkordi 1 ORCID logo, Hasan Banitalebi 2, Ali Hasanpour-Dehkordi 3 * ORCID logo

1 Medical Faculty, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Diagnostic Imaging, Akershus University Hospital, Norway
3 Social Determinants of Health Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Ali Hasanpour-Dehkordi, Email: alihassanpourdehkordi@gmail.com, hasanpour.A@skums.ac.ir


Patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or COVID-19 represents usually a variety range of symptoms related to influenza-like syndrome and respiratory tract infections. Likewise, kidney involvement and acute kidney injury (AKI) were reported in many previous studies. Although a hypovolemic circulation would be the most common reason in patients with AKI, some strong proofs are suggesting a cytokine storm due to immune system exaggeration and inflammation-mediated tubular injury in COVID-19 infections. The inflammatory response in cytokine storm leads to the high release of cytokines mostly including TNFα, IL-1β, IL-6, INFγ, IL-2, IL-7, and endothelial mediators. The main culprits in the AKI and consequent organ failure are resident leukocytes in specific tissues, activated following the cytokine release, and systemic inflammatory response. AKI management and cytokine profile evaluation should be highly emphasized in patients with COVID-19 to prevent the progression of chronic kidney disease or permanent renal failure. Treatment options in COVID-19 regarding no specific drugs should be supportive and based on stabilizing the patients; however, combination therapy with different antiviral have shown promising outcomes. As a result, utilizing the anti-TNFα and anti-IL-1 agents should be noticed if indicated. Additionally, the hematopoietic stem cell transplantation is a curative approach.
Keywords: Acute kidney injury, Cytokine storm, COVID-19, Cytokines

Implication for health policy/practice/research/medical education: We are willing to convey the fact that COVID-19 patients need to be more concerned about the renal system complications and acute kidney injury, in particular. Evidentially, it has been suggested that the severe inflammatory response triggered by COVID-19-mediated infection may have a crucial role in tissue damage in kidney and renal failure development. Hence, the lethal renal complications should be minded, especially in elderly who met the COVID-19 infection.

Please cite this paper as: Ebrahimi-Dehkordi S, Banitalebi H, Hasanpour-Dehkordi A. Acute kidney injury due to cytokine storm in patients with COVID-19 infection. J Nephropathol. 2021;10(4):e37. DOI: 10.34172/jnp.2021.37.

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Abstract View: 219

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Submitted: 14 Jun 2020
Accepted: 01 Jul 2020
ePublished: 22 Jul 2020
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