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J Nephropathol. 2021;10(4): e38.
doi: 10.34172/jnp.2021.38
  Abstract View: 156
  PDF Download: 54

Original Article

Interleukin-10 gene promoter variants and susceptibility to diabetic nephropathy; a meta-analysis

Gita Mishra 1 ORCID logo, Sudeep Gautam 2, Thavanati Parvathi Kumara Reddy 3 ORCID logo, Bhaskar VKS Lakkakula 1 * ORCID logo

1 Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, 495009 (CG), India
2 Section on Cellular Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
3 Departamento de Biología Molecular y Genomica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México
*Corresponding author: Prof. Bhaskar VKS Lakkakula, Email: lvksbhaskar@gmail.com

Abstract

Introduction: Diabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD) in diabetes patients. There is ample evidence that the inflammatory pathways are central to both diabetes and DN. Several studies that examined the link between the interleukin-10 (IL10) polymorphisms and DN risk yielded conflicting results.

Objectives: The purpose of this meta-analysis is to evaluate the associations between IL10 promoter polymorphisms and DN risk.

Methods: A bibliographic search was carried out on PubMed, Google scholar and Web of Science from the beginning until July 30, 2020. Association between IL10 promoter variants (-1082 A>G, -819 C>T and -592 C>A) and DN risk were assessed by considering diabetes without nephropathy (DWN) as well as healthy controls. Data were retrieved and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.

Results: For the IL10 -1082 A> G analysis, a total of 4 studies with DWN controls (682 cases and 529 controls) and 5 studies with healthy controls (1025 cases and 1625 controls) were considered. For the IL10 -819 C> T analysis, a total of three studies with DWN controls (9619 cases and 445 controls) and 5 studies with healthy controls (1005 cases and 1537 controls) were considered. For the IL10 -592 C> T analysis, a total of 5 studies with DWN controls (819 cases and 645 controls) and 5 studies with healthy controls (1005 cases and 1537 controls) were considered. In addition, there was no evidence of publication bias for IL10 promoter variants. No substantial association was observed between IL10 promoter variants and DN risk.

Conclusion: Our study signifies that polymorphisms of IL10 -1082 A>G, -819 C>T and -592 C>A are not linked with DN risk.

Keywords: Diabetic nephropathy, Interleukin-10, Promoter polymorphisms, Meta-analysis

Implication for health policy/practice/research/medical education: In the present study, we investigated the association between diabetic nephropathy and IL10 promoter variants using meta-analysis. This study demonstrated that the IL10 gene promoter variants (-1082 A>G, -819 C>T and -592 C>A) are not associated with the development of diabetic nephropathy.

Please cite this paper as: Mishra G, Gautam S, Kumara Reddy TP, Lakkakula BVKS. Interleukin-10 gene promoter variants and susceptibility to diabetic nephropathy; a meta-analysis. J Nephropathol. 2021;10(4):e38. DOI: 10.34172/jnp.2021.38.

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Submitted: 14 Aug 2020
Accepted: 05 Oct 2020
ePublished: 27 Oct 2020
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