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J Nephropathol. 2022;11(2): e17186.
doi: 10.34172/jnp.2022.17186
  Abstract View: 239
  PDF Download: 215

Case Report

Membranoproliferative glomerulonephritis in β-thalassemia intermedia; a case report

Maryam Shafiee 1 ORCID logo, Seyed Alireza Zomorodian 2* ORCID logo, Seyed Mohammad Owji 3 ORCID logo, Jamshid Roozbeh Shahroodi 1 ORCID logo, Mahsa Torabi Jahromi 1 ORCID logo

1 Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
*Corresponding Author: *Corresponding author: Seyed Alireza Zomorodian, Email; , Email: mil.zomorod@gmail.com

Abstract

Introduction: β-thalassemia intermedia reduces the body’s ability to produce adult hemoglobin and causes anemia. In contrast to β-thalassemia major, β-thalassemia intermedia patients do not require lifelong transfusion and are often independent of blood transfusion until young age. Moreover, chronic hypoxia and iron overload may cause tubular and glomerular dysfunction in patients with thalassemia.

Case Presentation: We report a 21-year-old female with β-thalassemia intermedia (β-TI) presenting with generalized edema and proteinuria and showed membranoproliferative glomerulonephritis (MPGN) after renal biopsy.

Conclusion: The possibility of occurrence of MPGN in patients with thalassemia should be considered. To our knowledge, it is the first case of thalassemia that was reported with MPGN and, more investigation is required to assess the association of thalassemia and MPGN.



Implication for health policy/practice/research/medical education:

We report a 21-year-old female with β-thalassemia intermedia presented with generalized edema and proteinuria, which renal biopsy showedmembranoproliferative glomerulonephritis.

Please cite this paper as: Shafiee M, Zomorodian SA, Owji SM, Roozbeh Shahroodi J, Torabi Jahromi M. Membranoproliferativeglomerulonephritis in β-thalassemia intermedia; a case report. J Nephropathol. 2022;11(2):e17186. DOI: 10.34172/jnp.2022.17186.


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Submitted: 17 Jan 2021
Accepted: 14 Jun 2021
ePublished: 02 Jul 2021
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