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J Nephropathol. 2023;12(2): e17247.
doi: 10.34172/jnp.2022.17247

Scopus ID: 85151396421
  Abstract View: 1392
  PDF Download: 238

Original Article

Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt

Wael Mostafa Hamza 1* ORCID logo, Ahmed Fayed 2 ORCID logo, Amr Mohamed Shaker 2 ORCID logo, Mahmoud Mohamed El Nokeety 2 ORCID logo

1 Department of Pathology, Cairo University, Faculty of Medicine, Kasr Al Aini Hospital, Cairo, Egypt
2 Department of Internal Medicine and Nephrology, Cairo University, Faculty of Medicine, Kasr Al Aini Hospital, Cairo, Egypt
*Corresponding Author: Corresponding author: Wael Mostafa Hamza, Email: , Email: wmhamza@kasralainy.edu.eg

Abstract

Introduction: Medical renal diseases stand as one of the major health problems in pediatric age group considering its morbidity/mortality and the subsequent management plans.

Objectives: In this manuscript, the spectrum of histopathological patterns of medical nephropathic lesions in Egyptian pediatric patients over duration of five years is reported with clinical indications.

Patients and Methods: We conducted a retrospective study for analysis of our pathological reports of renal needle biopsies during the period from January 2014 until January 2019. One hundred and sixteen cases were included.

Results: The most commonly encountered pediatric renal pathology was minimal change disease (27.59%), followed by congenital glomerular diseases (22.41%), focal segmental glomerulosclerosis (12.93%), and thrombotic microangiopathy (7.76%). The most common clinical indication for biopsy was nephrotic syndrome (37.07%) followed by impaired renal functions with elevated serum creatinine (21.55%). In addition, we report very rare histological findings in few cases including infantile nephropathic cystinosis, Barakat syndrome and C3 glomerulopathy.

Conclusion: Minimal change disease and congenital glomerular diseases accounted for half of pediatric renal pathologies in the study population. The most common clinical indication for renal biopsy was nephrotic syndrome. Electron microscopic examination and genetic studies are mandatory for proper evaluation of pediatric nephropathies.


Implication for health policy/practice/research/medical education:

In this manuscript, we provide a brief report about the frequency and patterns of medical renal diseases in pediatric patients from a single center in Egypt over duration of five years. Rare histopathological findings are presented in few cases.

Please cite this paper as: Hamza WM, Fayed A, Shaker AM, El Nokeety MM. Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt. J Nephropathol. 2023;12(2):e17247. DOI: 10.34172/jnp.2022.17247.

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Submitted: 22 Jun 2021
Accepted: 19 Dec 2021
ePublished: 08 Jan 2022
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