Tubulointerstitial nephritis and uveitis syndrome (TINU) combines tubulointerstitial nephritis and uveitis and is a known cause of kidney failure in children and adults. This is a challenging diagnosis since renal and ocular manifestations may not occur simultaneously and may be present in several alternative diagnosis. The authors report the case of a 28-year-old patient with acute kidney injury (AKI) and biopsy-proven acute tubulointerstitial nephritis. Bilateral symptomatic uveitis presented six months after the initial presentation. Physicians in charge of patients with kidney disease attributed to acute tubulointerstitial nephritis must bear in mind the need for ophthalmologic surveillance for at least one year post-diagnosis. Although a diagnosis of exclusion, its incidence may be higher than described. Kidney disease is believed to be self-limited and prognosis still, most patients will require systemic therapy and relapses are common.
Implication for health policy/practice/research/medical education:
This case illustrates the clinical course and diagnostic challenge of patients with tubulointerstitial nephritis and associated ophthalmologic pathology, highlighting the multidisciplinary approach required for an appropriate care.
Please cite this paper as: Carias E, Cabrita A, Leão Neves P, Silva AP. Take a closer look at TINU syndrome; analysis of a case. J Nephropathol. 2023;12(2):e17349. DOI: 10.34172/jnp.2022.17349.