J Nephropathol. 2023;12(1): e18376.
doi: 10.34172/jnp.2022.18376
  Abstract View: 175
  PDF Download: 56

Original Article

Evaluation of mortality of COVID-19 patients with acute kidney injury (AKI) in comparison to the non-AKI patients

Heshmatollah Shahbazian ORCID logo, Mina Tafazoli* ORCID logo, Leila Sabet Nia ORCID logo, Ali Ghorbani ORCID logo, Shahla Ahmadi Halili ORCID logo, Fatemeh Jahangiri Mehr ORCID logo

1 Chronic Renal Failure Research Center, Ahvaz, Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: Corresponding author: Mina Tafazoli, Email: , Email: mtafazoli414@gmail.com


Introduction: Acute kidney injury (AKI) is prevalent in the coronavirus disease-2019 (COVID-19). There are little data on the relationship between renal dysfunction and COVID-19 prognosis.

Objectives: The aim of this research was to investigate the effects of AKI in COVID-19 patients hospitalized to the Golestan and Razi hospitals in Ahvaz, Iran.

Patients and Methods: In this retrospective cohort study, a total of 194 COVID-19 patients were included, consisting of 79 patients with AKI and 115 patients without AKI. Primary and secondary outcomes were compared between the two groups.

Results: According to the findings, mortality was significantly different between the two groups, and mortality was higher in the AKI group (P< 0.001). The mean length of hospital stay was statistically significantly higher in the AKI group (P=0.024). Moreover, there was a significant correlation between intensive care unit (ICU) admission and the study group (P<0.001). Staging of AKI group were seen as; stage I (49.37%), stage II (36.71%), and stage III (13.92%). No significant correlation was observed between outcome and the stages of AKI (P=0.496). Furthermore, 14 patients (17.72%) needed renal replacement therapy (RRT) in the AKI group.

Conclusion: Although AKI is a common finding in COVID-19 patients, most patients were in stage I disease, which returned to normal after COVID-19 treatment. According to our research, COVID-19 rarely leads to serious and persistent kidney injury. However, the risk of death is increased in COVID-19 patients with AKI. Therefore, it is necessary to evaluate the renal function tests during the course of disease.

Implication for health policy/practice/research/medical education:

Some studies reported that the incidence of acute kidney injury (AKI) in COVID-19 patients was higher than the incidence of AKI in non-COVID-19 patients. The study was conducted on 194 COVID-19 patients admitted to Golestan and Razi hospitals in Ahvaz, Iran. According to our results, COVID-19 does not cause serious and permanent kidney injury. Since the rate of mortality of COVID-19 patient is higher in the AKI group, it is recommended that patients with COVD-19 should be assessed for AKI.

Please cite this paper as: Shahbazian H, Tafazoli M, Sabet Nia L, Ghorbani A, Ahmadi Halili S, Jahangiri Mehr F. Evaluation of mortality of COVID-19 patients with acute kidney injury (AKI) in comparison to the non-AKI patients. J Nephropathol. 2023;11(1):e18376. DOI: 10.34172/jnp.2022.18376.

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Submitted: 14 May 2022
Accepted: 09 Jul 2022
ePublished: 20 Aug 2022
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