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J Nephropathol. 2024;13(1): e18379.
doi: 10.34172/jnp.2022.18379

Scopus ID: 85178962090
  Abstract View: 1078
  PDF Download: 132

Original Article

COVID-19 in patients under maintenance hemodialysis; clinical characteristics, laboratory findings and treatments

Ali Hasanvand 1, Leila Sabetnia 2 ORCID logo, Farzaneh Hematian 3 ORCID logo, Amir Jamshidnezhad 4 ORCID logo, Leila Kouti 3* ORCID logo

1 Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Clinical Pharmacy, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Health Information Technology, Faculty of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: Corresponding author: Leila Kouti, Email: leilakouti2@gmail.com, , Email: kouti-l@ajum.ac.ir

Abstract

Introduction: The patients undergoing maintenance hemodialysis (MHD) who are affected with COVID-19 may be at a higher risk for severe disease and complications. Considering the current COVID-19 pandemic, there is a need for studies investigating the various aspects of COVID-19 in patients with MHD.

Objectives: The present study aimed to identify the risk factors associated with higher COVID-19- related mortality in patients under MHD.

Patients and Methods: The present retrospective study included 90 patients under MHD who were hospitalized with COVID-19 and diagnosed using the reverse transcription polymerase chain reaction (RT-PCR) from March 20, 2020, to December 20, 2020.

Results: The participants’ mean age was 57.5±18.61 years, and 49 patients (54.4%) were men. Moreover, 35 patients (38.9%) were expired due to COVID-19. The most common underlying diseases included diabetes mellitus, hypertension and cardiovascular diseases. The patients expired due to COVID-19 had a significantly higher chance of needing oxygen therapy, mechanical ventilation, and intensive care unit admission compared to survived patients. Moreover, a significant negative relationship between mineral-multivitamin supplementation and COVID-19-related mortality was detected. The prevalence of dyspnea was significantly higher in the expired patients compared to survived patients.

Conclusion: The COVID-19 patients under MHD are high-risk for severe disease and mortality. Therefore, hemodialysis centers should establish strict preventive measures.


Implication for health policy/practice/research/medical education:

Maintenance hemodialysis (MHD) could be a risk factor for COVID-19 prognosis partly due to the drug regimen of the patients. In our 90 MHD patients infected with COVID-19 who were treated with seven different drug regimens, we found patients expired due to COVID-19 had a significantly higher chance of needing oxygen therapy, mechanical ventilation, and intensive care unit admission compared to the survived patients.

Please cite this paper as: Hasanvand A, Sabetnia L, Hematian F, Jamshidnezhad A, Kouti L. COVID-19 in patients under maintenance hemodialysis; clinical characteristics, laboratory findings and treatments. J Nephropathol. 2024;13(1):e18379. DOI: 10.34172/ jnp.2022.18379.

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Submitted: 02 May 2022
Accepted: 22 Jun 2022
ePublished: 08 Oct 2022
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