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J Nephropathol. 2017;6(4): 352-355.
doi: 10.15171/jnp.2017.57

Scopus ID: 85036584059
  Abstract View: 2373
  PDF Download: 1365

Original Article

Association of serum fibroblast growth factor 23 with calcium metabolism in patients with end-stage renal disease undergoing hemodialysis

Niloufar Alimohammadi 1, Parisa Javadian 2*, Afsaneh Malekpour 3, Shahram Tahmasebian 4

1 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Community Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Genetic, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: *Corresponding author: Parisa Javadian, Email: javadianp@gmail.com

Abstract

Background: The association between the function of fibroblast growth factor 23 (FGF23) and different components of calcium metabolism has remained unclear in patients with renal dysfunction undergoing hemodialysis.

Objectives: The present study aimed to assess the association of the level of FGF23 and calcium metabolism status in hemodialysis patients. Patients and Methods: This cross-sectional study conducted on 90 consecutive patients suffering end-stage renal disease (ESRD) who underwent hemodialysis. The serum levels of FGF23 and intact parathyroid hormone (iPTH) levels were measured using the ELISA technique.

Results: The serum levels of FGF23 were directly associated with iPTH level (r = 0.251, P = 0.020) and slightly with the duration of dialysis (r = 0.203, P = 0.063). However serum FGF23 was not significantly related to other indices including levels of calcium, phosphorus, magnesium, vitamin D, albumin, and even body mass index (BMI). No difference was found in the level of FGF23 between men and women with ESRD under hemodialysis.

Conclusions: In ESRD patients undergoing hemodialysis, the association of FGF23 with iPTH was detected, while there was not any relationship of FGF23 with other indices including calcium, phosphorus, and vitamin D.


Implication for health policy/practice/research/medical education: In a cross-sectional study conducted on 90 consecutive stable hemodialysis patients, we found that FGF23 influences the bone metabolism in ESRD patients.

Please cite this paper as: Alimohammadi N, Javadian P, Malekpour A, Tahmasebian S. Association of serum fibroblast growth factor 23 with calcium metabolism in patients with end-stage renal disease undergoing hemodialysis. J Nephropathol. 2017;6(4):352-355. DOI: 10.15171/jnp.2017.57

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Submitted: 29 Mar 2017
Accepted: 20 Jun 2017
ePublished: 16 Jul 2017
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