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J Nephropathol. 2018;7(1): 22-24.
doi: 10.15171/jnp.2018.08

Scopus ID: 85046546702
  Abstract View: 2861
  PDF Download: 1505

Case Report

Infant onset systemic lupus erythematosus presenting as nephrotic syndrome

Pouneh Dokouhaki 1, Assel Rakhmetova 1,2*, Abdullah Alabbas 3

1 Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
2 Research Fellow, International Society of Nephrology, Brussels, Belgium
3 Department of Pediatrics, Division of Nephrology, University of Alberta, Edmonton, Canada
*Corresponding Author: *Corresponding author: Assel Rakhmetova, , Email: rakhmeto@ualberta.ca

Abstract

Background: Membranous nephropathy (MGN) is one of the most common glomerular disease seen among adults. However, it is a rare histological presentation in pediatric population. In contrast to MGN in adults where primary form is known to be the leading subtype of the disease, secondary cause is more prevailing in children.

Case Presentation: We describe a case of an infant presenting with nephrotic syndrome (NS) and negative serology work-up. Kidney biopsy showed the picture of severe diffuse MGN confirmed by light, immunofluorescence and electron microscopy studies. “Full-house” pattern by immunofluorescence, numerous well-demarcated sub-epithelial deposits and tubuloreticular inclusions strongly suggested type V lupus nephritis.

Conclusions: NS due to MGN is rarely seen in infancy. Secondary causes such as autoimmune disease or systemic infection need to be considered for appropriate management.


Implication for health policy/practice/research/medical education:

Membranous glomerulonephritis is uncommon in children and in contrast to adults, is commonly due to secondary causes. Therefore, extensive investigations in children with membranous nephropathy (MGN) is necessary to rule out the underlying disorders, such as systemic lupus erythematosus or infections.

Please cite this paper as: Dokouhaki P, Rakhmetova A, Alabbas A. Infant onset systemic lupus erythematosus presenting as nephrotic syndrome. J Nephropathol. 2018;7(1):22-24. DOI: 10.15171/jnp.2018.08.

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Submitted: 14 Jun 2017
Accepted: 19 Oct 2017
ePublished: 17 Dec 2017
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