Background: Chronic kidney disease (CKD) is a consequence of progressive and irreversible
destruction of nephrons, mainly due to uncontrolled diabetes mellitus and high blood
pressure. Ghrelin is a peptide hormone which could play a substantial role in hunger
sensation, may increase body fat percentage and might adjust the long-term body weight
and is mostly secreted in the stomach.
Objectives: This study aimed to evaluate the relationship between ghrelin levels and various
biochemical and demographic indices in a group of non-diabetic hemodialysis patients.
Patients and Methods: Around 39 non-diabetic patients undergoing hemodialysis in Hajar
hospital at Shahrekord city were enrolled.
Results: The mean age of patients was 57.10±20.20 years. Their mean weight was 56.65
±16.25 kg. Their hemoglobin level mean was 10.43±1.84 g/dL. The serum ghrelin level
had a positive but not significant correlation with the age, dialysis quality, dosage, calcium
level, alkaline phosphatase (ALP), parathormone, vitamin D and hemoglobin in these
Conclusions: More studies in this subject of hemodialysis patients to define the exact role of
ghrelin in hemodialysis patients are recommended.
Implication for health policy/practice/research/medical education:
In a study on 39 non-diabetic patients undergoing hemodialysis, we found that serum ghrelin level had a positive but not
significant correlation with the age, dialysis quality, dosage, calcium level, alkaline phosphatase (ALP), parathormone, vitamin
D and hemoglobin in these patients.
Please cite this paper as: Mahmoodnia L, Beigrezaei S, Tamadon MR, Jafari T, Kafeshani M, Mahmoodi F, et al. The relationship
between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot
study. J Nephropathol. 2018;7(1):32-36. DOI: 10.15171/jnp.2017.10.