Leila Mahmoodnia
1, Sara Beigrezaei
2, Mohammad Reza Tamadon
3, Tina Jafari
4, Marzieh Kafeshani
5, Fatemeh Mahmoodi
1, Ali Hasanpour Dehkordi
6, Masoud Amiri
7*1 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran
4 Department of Biochemistry and Nutrition, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord
5 Food Security Research Center and Department of Clinical Nutrition/Community Nutrition/Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
6 Social determinants of Health Research Center/Department of Medical-Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran
7 Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Background: Chronic kidney disease (CKD) is a consequence of progressive and irreversible
destruction of nephrons, mainly due to uncontrolled diabetes mellitus and high blood
pressure. Ghrelin is a peptide hormone which could play a substantial role in hunger
sensation, may increase body fat percentage and might adjust the long-term body weight
and is mostly secreted in the stomach.
Objectives: This study aimed to evaluate the relationship between ghrelin levels and various
biochemical and demographic indices in a group of non-diabetic hemodialysis patients.
Patients and Methods: Around 39 non-diabetic patients undergoing hemodialysis in Hajar
hospital at Shahrekord city were enrolled.
Results: The mean age of patients was 57.10±20.20 years. Their mean weight was 56.65
±16.25 kg. Their hemoglobin level mean was 10.43±1.84 g/dL. The serum ghrelin level
had a positive but not significant correlation with the age, dialysis quality, dosage, calcium
level, alkaline phosphatase (ALP), parathormone, vitamin D and hemoglobin in these
patients.
Conclusions: More studies in this subject of hemodialysis patients to define the exact role of
ghrelin in hemodialysis patients are recommended.
Implication for health policy/practice/research/medical education:
In a study on 39 non-diabetic patients undergoing hemodialysis, we found that serum ghrelin level had a positive but not
significant correlation with the age, dialysis quality, dosage, calcium level, alkaline phosphatase (ALP), parathormone, vitamin
D and hemoglobin in these patients.
Please cite this paper as: Mahmoodnia L, Beigrezaei S, Tamadon MR, Jafari T, Kafeshani M, Mahmoodi F, et al. The relationship
between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot
study. J Nephropathol. 2018;7(1):32-36. DOI: 10.15171/jnp.2017.10.