Mehdi Nematbakhsh
1,2,3*1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
3 IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran
Abstract
The two important arms of renin angiotensin system (RAS) are angiotensin II (Ang II) and
angiotensin1-7 (Ang1-7). Both of these peptides are present in the kidney, while the renal
hemodynamic responses to these peptides act differently in kidney circulation.
For this short-review, we used a variety of sources including PubMed, Google Scholar, and
Scopus.
Although in normal physiological condition, Ang1-7 has been known as an inactive agent
in the renal system, however in past years many experimental and clinical reports indicated
the protective role of Ang1-7 in renal hemodynamics and functions under different
circumstances. In the current article, the possible renoprotective role of Ang1-7 was briefly
reviewed.
Implication for health policy/practice/research/medical education:
The protective role of angiotensin 1-7 in renal system mostly related to the improvement of endothelial function or struggle
with serious hazard and damage induced by angiotensin II in the kidney.
Please cite this paper as: Nematbakhsh M. Renoprotective impact of angiotensin 1-7: Is it certain? J Nephropathol. 2019;8(1):e01.
DOI: 10.15171/jnp.2019.01.