Leila Mahmoodnia
1 
, Shahin Asgari Savadjani
1 , Leila Mostafavi
2 , Setayesh Sotoudehnia Korani
3 , Fatemeh Mohammad Alizadeh
4 , Mahshid Sadat Chenarani Moghadam
5, Hamid Reza Jahantigh
6 , Sina Neshat
7* , Ali Shirbacheh
8 , Jyoti Baharani
9 , Rohollah Masomi
1* , Zahra Golestani Hotkani
101 Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
3 Department of Radiology, Mayo Clinic, Rochester, MN, United States
4 Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children’s Hospital, Boston, MA, United States
5 Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands
6 Department of Pathology, Faculty of Medicine, Emory University, Atlanta, GA, USA
7 Department of Pulmonology, Mayo Clinic, Jacksonville 32224 FL, USA
8 Urgences, Centre Hospitalier de Niort, Niort, France
9 University Hospitals Birmingham B95SS, United Kingdom
10 Department of Bioscience, University of Milan, Milan, Italy
Abstract
IgA vasculitis nephritis (Schönlein-Henoch purpura nephritis) is an autoimmune circumstance characterized by palpable purpura involving the lower limbs, arthralgia, abdominal pain and kidney involvement. It is possible that a cytokine storm following coronavirus disease 2019 (COVID-19) could lead to an immunological dysregulation responsible for IgA vasculitis nephritis in these cases. Reactivation or first onset of IgA vasculitis nephritis is uncommon; however, there have been increasing reports of this disease, as a complication of COVID-19 vaccination. It is possible that COVID-19 mRNA vaccination may trigger several auto-inflammatory and autoimmune cascades. Previous research has shown that Toll-like receptors play a role in the development of IgA vasculitis nephritis. Following injection of a COVID-19 mRNA vaccine, the uptake of double-stranded RNA by-products will trigger Toll-like receptors, leading to a series of intracellular cascades starting an innate immunity-driven process of cell-mediated and humoral- mediated immunity.
Implication for health policy/practice/research/medical education:
COVID-19 mRNA vaccines provoke IgA vasculitis nephritis (Schönlein-Henoch purpura nephritis); though a coincidence disease should also be envisaged.
Please cite this paper as: Mahmoodnia L, Asgari Savadjani S, Mostafavi L, Sotoudehnia Korani S, Mohammad Alizadeh F, Chenarani Moghadam MS, Jahantigh HR, Neshat S, Shirbacheh A, Baharani J, Masomi R, Golestani Hotkani Z. IgA vasculitis nephritis (Schönlein-Henoch purpura with nephritis) following COVID-19 vaccination. J Nephropathol. 2023;12(2):e21447. DOI: 10.34172/jnp.2023.21447.