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J Nephropathol. 2024;13(1): e21461.
doi: 10.34172/jnp.2023.21461

Scopus ID: 85178926225
  Abstract View: 692
  PDF Download: 100

Original

Galangin attenuates adenine-induced chronic renal failure by inhibiting transforming growth factor beta (TGF-β) expression

Deepthi Rayilla ORCID logo, Ganta Suhasin* ORCID logo

1 Department of Pharmacology, GITAM School of Pharmacy, GITAM Deemed to be University, Visakhapatnam 530045, Andhra Pradesh, India
*Corresponding Author: Ganta Suhasin, Email: sganta@gitam.edu

Abstract

Introduction: Galangin (3,5,7 tri-hydroxy flavone), naturally active flavonoid is derived from the rhizomes of Alpinia officinarum is proven to be effective antioxidant, anti-inflammatory, anti-cancer. However, protective effects of galangin in chronic renal failure (CRF) is not explored.

Objectives: This study is aimed to investigate the nephroprotective activity of galangin in adenine-induced CRF rats.

Materials and Methods: Adenine induced rats were administered galangin 20 mg/kg and 40 mg/kg body weight (BW) serum renal and hepatic parameters, and renal antioxidant-lipid peroxidation parameters, histological studies were carried out. The mechanism of action was investigated by flow cytometry.

Results: Galangin has normalized serum renal and hepatic parameters, reduced oxidative stress and lipid peroxidation. Histopathology confirms nephroprotection. The percentage number of cells expressing transforming growth factor beta (TGF-β) was reduced with galangin treatment.

Conclusion: Galangin exerts nephroprotection in adenine induced CRF by inhibiting TGF-β expression.


Implication for health policy/practice/research/medical education:

The data suggests that galangin administration in rats has reduced the progression of chronic renal failure in adenine induced CRF. Thus, it can be a useful alternate or adjunct in CRF.

Please cite this paper as: Rayilla D, Suhasin G. Galangin attenuates adenine-induced chronic renal failure by inhibiting transforming growth factor beta (TGF-β) expression. J Nephropathol. 2024;13(1):e21461. DOI: 10.34172/jnp.2023.21461.

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Submitted: 22 Mar 2023
Accepted: 08 Jun 2023
ePublished: 23 Sep 2023
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