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J Nephropathol. 2024;13(4): e21530.
doi: 10.34172/jnp.2024.21530

Scopus ID: 85202587096
  Abstract View: 402
  PDF Download: 77

Meta-analysis

The association between statin use and non-Hodgkin lymphoma; a systematic review and meta-analysis

Anna Ghorbani Doshantapeh 1 ORCID logo, Atieh Nouralishahi 2 ORCID logo, Anahid Cheraghalian 3 ORCID logo, Navid Asgari 4 ORCID logo, Razieh Bagheri Shahzadeh Aliakbari 5 ORCID logo, Nasim Zaman Samghabadi 6 ORCID logo, Mostafa Assarroudi 7 ORCID logo, Elahe Zaremoghadam 8,9 ORCID logo, Seyede Sara Pakdaman Kolour 10* ORCID logo

1 Department of Hematology-Medical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Sub-Department of Operations and Analytics, Department of Management, Faculty of Environment, Science and Economy, University of Exeter, Exeter, United Kingdom
3 General Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 College of Applied and Natural Sciences, Louisiana Tech University, Ruston, Louisiana, USA
6 Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
7 Department of Nursing, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
8 Department of Internal Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
9 Guissu Research Corporation, Bandar Abbas, Iran
10 Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
*Corresponding Author: Seyede Sara Pakdaman Kolour, Email: sara.pakdaman20@gmail.com

Abstract

Introduction: Statins reduce the cancer risk; however, non-Hodgkin lymphoma (NHL) evidence remains controversial. Therefore, we aimed to evaluate the relationship between statin consumption and NHL risk using a systematic review and meta-analysis.

Materials and Methods: In this systematic review and meta-analysis, international databases, including Scopus, PubMed, Web of Science, Cochrane, and Google Scholar search engines, were searched without a time limit up to September 21, 2023. Data analysis was performed using STATA 14 software, and the significance level was considered P<0.05.

Results: The results of combining 13 studies (9 case-control studies and 4 cohort studies) with a total sample size of 1142 740 subjects showed that statin consumption could reduce NHL risk by 22% (RR: 0.78; 95% CI: 0.69, 0.88). Statin consumption in cohort studies reduced NHL risk by 14% (RR: 0.86; 95% CI: 0.77, 0.95), but in case-control studies, it reduced NHL risk by 26% (RR: 0.74; 95% CI: 0.62, 0.90). Furthermore, statin consumption reduced diffuse large B-cell lymphoma risk by 24% (RR: 0.76; 95% CI: 0.67, 0.87) and marginal zone risk by 26% (RR: 0.74; 95% CI: 0.59, 0.93). However, it did not affect reducing the risk of chronic lymphocytic leukemia/small lymphocytic lymphoma (RR: 0.94; 95% CI: 0.85, 1.05), follicular (RR: 0.96; 95% CI: 0.83, 1.10), plasma cell neoplasms (RR: 0.97; 95% CI: 0.70, 1.33), T cell lymphoma (RR: 0.81; 95% CI: 0.55, 1.19) and B cell lymphoma (RR: 0.94; 95% CI: 0.44, 2.01).

Conclusion: Statin consumption significantly reduced the risk of NHL, diffuse large B-cell lymphoma, and marginal zone but did not affect other NHL types.

Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023469126) and Research Registry (UIN: reviewregistry1732) website.


Implication for health policy/practice/research/medical education:

In a meta-analysis study on the correlation between statin consumption and NHL, we found that statin consumption significantly reduced the risk of NHL, diffuse large B-cell lymphoma, and marginal zone but did not affect other NHL types. This suggests that statins may have a protective effect specifically on certain subtypes of NHL.

Please cite this paper as: Ghorbani Doshantapeh A, Nouralishahi A, Cheraghalian A, Asgari N, Bagheri Shahzadeh Aliakbari R, Zaman Samghabadi N, Assarroudi M, Zaremoghadam E, Pakdaman Kolour SS. The association between statin use and non-Hodgkin lymphoma; a systematic review and meta-analysis. J Nephropathol. 2024;13(4):e21530. DOI: 10.34172/jnp.2024.21530.

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Submitted: 15 Oct 2023
Accepted: 13 Jan 2024
ePublished: 24 Jun 2024
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