Saeed Hoseininia
, Sousan Mohammadi Kebar
* 1 Department of Internal Medicine, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract
Familial Mediterranean fever is an autosomal recessive autoinflammatory disorder characterized by recurrent episodes of fever, inflammation, and serositis. Individuals with Familial Mediterranean fever (FMF) are at an increased risk of developing various renal diseases, comprising IgA nephropathy. IgA nephropathy is one of the most frequently reported non-amyloid renal diseases observed in the familial Mediterranean fever. The mechanism linking this disorder and IgA nephropathy related to the chronic inflammatory state associated with familial Mediterranean fever.
Implication for health policy/practice/research/medical education:
Amyloidosis is the primary renal complication of familial Mediterranean fever that can lead to end-stage renal disease by causing proteinuria and nephrotic syndrome. However, other non-amyloid renal manifestations of familial Mediterranean fever include glomerular diseases like IgA nephropathy and tubulointerstitial nephritis.
Please cite this paper as: Hoseininia S, Mohammadi Kebar S. IgA nephropathy-associated familial Mediterranean fever. J Nephropathol. 2025;14(1):e26557. DOI: 10.34172/jnp.2025.26557.