Shirin Taraz Jamshidi
1 
, Salman Soltani
2 , Hamidreza Ghorbani
2 , Tina Zeraati
3 , Naser Tayyebimeibodi
4 , Atena Aghaee
5 , Ali Emadzadeh
6* 1 Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Kidney Transplantation Complications Research Center, Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Cardiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
4 Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6 Department of Internal Medicine, MMS.C., Islamic Azad University, Mashhad, Iran
Abstract
Hemangioblastoma is a benign tumor of central nervous system (CNS) which may rarely occur in extraneural tissues. Renal hemangioblastoma (RH) occurs sporadic or in the setting of Von-hipple-lindau syndrome. It is usually misdiagnosed as other renal masses including renal cell carcinoma (RCC) due to their similar clinical and histologic features. In this paper, we present two cases of RH which resembled RCC, however immunohistochemical studies confirmed diagnosis of RH.
Implication for health policy/practice/research/medical education:
Renal hemangioblastoma (RH) is a mimicker of real cell carcinoma, clinically and histologically. Attention to immunohistochemical profile of this tumor leads to the correct diagnosis and prevents unnecessary nephrectomy.
Please cite this paper as: Taraz Jamshidi Sh, Soltani S, Ghorbani H, Zeraati T, Tayyebimeibodi N, Aghaee A, Emadzadeh A. Sporadic hemangioblastoma of the kidney; a rare entity and a potential diagnostic challenge. J Nephropathol. 2025;x(x):e26569. DOI: 10.34172/jnp.2025.26569.