Abstract
Background: Chronic kidney disease (CKD) and uremic syndrome cause malfunction in most of
organs including skin.
Objectives: This study was designed to investigate the effects of omega-3 supplement on uremic
pruritus in chronic hemodialysis patients.
Patients and Methods: In this double-blind randomized controlled clinical trial study (#IRCT cod;
29363; http://irct.ir/trial/29363), the effect of the omega-3 supplement on uremic pruritus was
assessed in 64 chronic hemodialysis patients (using standard 5-D itch scale questionnaire). Patients
were surveyed at the hemodialysis department of Imam Khomeini and Razi hospitals in Ahvaz city,
Iran.
Results: We found that the mean score of itching degree in the intervention and the placebo groups
decreased from 3.56 to 1.72 (P<0.001) and 3.63 to 3.09 (P<0.05) respectively.
Conclusions: In our study, the omega-3 supplement could reduce uremic pruritus in chronic
hemodialysis patients.