Ali Thoulfikar A. Imeer
1* 
, Abdul Amir H. Kadhum
1 , Qais R. Lahhob
2 , Hussein Ali Al-Bahrani
3 , Maytham Ahmed Abdul Aemah
4 , Omer Mansib Kassid
5 1 College of Medicine, University of Al-Ameed, Karbala, Iraq
2 College of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq
3 Department of Chemistry, College of Education for Pure Science, University of Kerbala, Karbala Iraq
4 College of Pharmacy, Al-Mustaqbal University, Babylon, Hillah, 51001, Iraq
5 College of Medicine, University of Misan, 62001 Misan, Iraq
Abstract
Allopurinol, primarily used to treat gout, has shown potential as an antihypertensive agent due to its effects on oxidative stress and endothelial function. This agent is not typically used as a first-line treatment for hypertension; however, some studies have suggested that it may have potential antihypertensive effects. More research is needed to establish its efficacy and mechanisms in treating hypertension.
Implication for health policy/practice/research/medical education:
High levels of uric acid have been associated with hypertension, and by lowering uric acid levels, allopurinol may help improve endothelial function and reduce oxidative stress, which can contribute to hypertension.
Please cite this paper as: A. Imeer AT, Kadhum AAH, Lahhob QR, Al-Bahrani HA, Abdul Aemah MA, Kassid OM. Antihypertensive efficacy of allopurinol; a mini-review on current concepts. J Nephropathol. 2025;14(4):e27587. DOI: 10.34172/jnp.2025.27587.