Neutropenia associated with proximal renal tubular dysfunction and mild bilateral cataract

Mitra Naseri ¹^* , Hamid Farhangi ² , Armin Attaran Zadeh ³, Zeynab Ghoroneh ¹

¹ Pediatric Nephrology Department, Mashhad University of Medical Sciences, Mashhad, Iran
² Pediatric Hematology and Oncology Department, Mashhad University of Medical Sciences, Mashhad, Iran
³ Pathology Section, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

*Corresponding Author: *Corresponding author: Mitra Naseri, Email: , Email: naserim@mums.ac.ir

Abstract

We report an 11-year-old girl admitted to nephrology section due to growth failure, neutropenia, renal glycosuria, and proteinuria and also hypophosphatemic rickets. She had a history of repeated hospitalization because of respiratory or gastrointestinal infections. Bone marrow aspiration revealed hyper-cellular bone marrow with mild dysplastic pattern. Eyes examination showed mild bilateral posterior cataract. X-ray of the wrist demonstrated a bone age of 3.5 ±6 months with evidence of rickets. We could not find a syndrome that can explain these associations.

Keywords: Fanconi syndrome, Neutropenia, Cataract, Hypophosphatemic rickets, Fanconi syndrome

Implication for health policy/practice/research/medical education: When encounter patients with chronic neutropenia and hypercellular bone marrow, systemic diseases with multi-organs (CNS, muscles, liver, joints and renal) involvements should be considered. Please cite this paper as: Naseri M, Farhangi H, Attaran Zadeh A, Ghoroneh Z. Neutropenia associated with proximal renal tubular dysfunction and mild bilateral cataract. J Nephropathol. 2021;10(x):exx. DOI: 10.34172/jnp.2021.xx.