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J Nephropathol. 2020;9(2): e19.
doi: 10.34172/jnp.2020.19

Scopus ID: 85079849086
  Abstract View: 2393
  PDF Download: 782

Case Report

A case of Fanconi syndrome as a complication of treatment with a checkpoint inhibitor in a patient with hepatocellular carcinoma

Mohammad Tinawi 1, Bahar Bastani 2* ORCID logo

1 Nephrology Specialists, P.C. 801 MacArthur Blvd., Ste. 400A, Munster, IN 46321, USA
2 Division of Nephrology, Saint Louis University Health Sciences Center, 3635 Vista Ave, St. Louis, MO, USA
*Corresponding Author: *Corresponding author: Prof. Bahar Bastani, M.D., Email: , Email: Bahar.Bastani@health.slu.edu

Abstract

Introduction: Immune checkpoint inhibitors (CPIs) represent novel new cancer immunotherapy agents. The use of nivolumab has been linked with immune mediated acute interstitial nephritis (AIN).

Case Presentation: We present the case of a patients with recurrent hepatocellular carcinoma who developed severe Fanconi syndrome, as evidenced by hyperchloremic metabolic acidosis, hypokalemia, hypophosphatemia, glucosuria, aminoaciduria, 8 months after initiating treatment with nivolumab, without any evidence of acute renal insufficiency.

Conclusion: Clinicians need to be aware of the renal side effects of new novel cancer immunotherapy agents, such as, immune CPIs


Implication for health policy/practice/research/medical education:

Clinicians need to be aware of the renal side effects of new novel cancer immunotherapy agents, such as, immune checkpoint inhibitors.

Please cite this paper as: Tinawi M, Bastani B. A case of Fanconi syndrome as a complication of treatment with a checkpoint inhibitor in a patient with hepatocellular carcinoma. J Nephropathol. 2020;9(2):e19. DOI: 10.34172/jnp.2020.19.

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Submitted: 04 Jul 2019
Accepted: 27 Jul 2019
ePublished: 10 Sep 2019
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