Kamal Khademvatani
1 
, Zahra Yekta
2 , Mirhosein Seyed Mohammadzad
3 , Shahriar Khanahmadi
4* , Roghaiyeh Afsargharehbagh
5 , Leila Majdi
4 , Alireza Rostamzadeh
6 , Mojgan Hajahmadipoor Rafsanjani
5 , Ali Soleimany
6 , Elham Niknejad
7 , Mohammad Reza Zolfaghari
8 , Shima Khanahmadi
4, Zeinab Pourmansouri
9 , Reza Karimi
4 1 Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran
2 Department of Community Medicine, Urmia University of Medical Sciences, Urmia, Iran
3 Patient Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran
4 Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
5 Department of Cardiology, Shohada Hospital, Urmia University of Medical sciences, Urmia, Iran
6 Urmia University of Medical Sciences, Urmia, Iran
7 Department of Dentistry, Urmia University of Medical Sciences, Urmia, Iran
8 Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia University of Medical Sciences, Urmia, Iran
9 Department of Clinical Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Introduction: Klotho allele status is associated with increased risk of cardiovascular diseases, diabetes and hypertension.
Objectives: To determine if serum klotho level was lower among diabetic and hypertensive patients compared to control group.
Patients and Methods: This was a cross-sectional study of 90 participants. Thirty pure diabetic patients and 30 participants with pure hypertension were compared with the healthy control group. Multiple logistic regressions were used to examine the association between serum klotho and diabetes and hypertension. We also tested the cut off point of serum klotho to predict hypertension and diabetes by using ROC (receiver operating characteristic) curve.
Results: The level of serum klotho was significantly lower in diabetic and hypertensive patients. Participants with higher klotho were less likely to have diabetes and hypertension [OR: 0.48, 95% CI (0.22-0.81)] even after adjustment for covariates. ROC curve for diabetes and hypertension indicated 0.8 area under the curve which was statistically significant.
Conclusion: This study found that serum klotho was associated with lower odds of diabetes and hypertension. Further longitudinal studies are necessary to confirm this finding.
Implication for health policy/practice/research/medical education:
Klotho is a recently known anti-aging protein. Diabetes and hypertension as two major public health issues associate with increased risk of cardiovascular complications. The level of serum klotho was significantly lower in diabetic and hypertensive patients. Serum klotho was associated with lower odds of diabetes and hypertension and participants with higher klotho were less likely to have diabetes and hypertension.
Please cite this paper as: Khademvatani K, Yekta Z, Seyed Mohammadzad M, Khanahmadi S, Afsargharehbagh R, Majdi L, et al. The predictive value of serum klotho in diabetes mellitus and hypertension. J Nephropathol. 2021;10(1):e07. DOI: 10.34172/jnp.2021.07.