Mohamad Ali Dayani
1* 
, Azin Mirzazadeh
2 1 Department of Radiology, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Joint Bioinformatics Graduate Program, University of Arkansas Little Rock and University of Arkansas for Medical Sciences, Little Rock, AR, USA
Abstract
Contrast agents are non-biologically active substances required for various diagnostic imaging
procedures. Exposure to contrast materials, predispose some patients to renal disturbances entitled
as contrast-associated acute kidney injury. Nephropathy of contrast medium is a deterioration of
renal function which happens within 24 to 72 hours after iodinated contrast medium injection.
Cancer individuals have several risk factors for contrast-associated acute renal failure, consisting of
administration of chemotherapy regimen, which are mainly nephrotoxic, presence of diabetes or
chronic renal failure, hypertension, taking of non-steroidal anti-inflammatory drugs, simultaneous
use of nephrotoxic drugs, aminoglycosides, cisplatin, cyclosporine A or amphotericin B, increases
the risk of contrast-associated acute renal failure. Similarly, age more than65 years old and anemia
is an independent risk factor for contrast-associated acute kidney injury and also timing of CT
within 45 days after last chemotherapy and low fluid intake, as the common risk factors in cancer
individuals.
Implication for health policy/practice/research/medical education:
Chemotherapy regimen dose adjustment is indispensable for cancer individuals. Accordingly, evaluation of kidney function is crucial when
Administrating intravascular contrast agents for computed tomography examinations of cancer individuals. Therefore, it is important to
keep in mind that why individuals with malignancy are at somewhat higher risk of contrast nephropathy than the general population.
Please cite this paper as: Dayani MA, Mirzazadeh A. Prevention of contrast-associated acute kidney injury in cancer patients undergoing
radiologic investigation using contrast media; a short-review to current knowledge. J Nephropathol. 2019;8(4):e43. DOI: 10.15171/
jnp.2019.43.