Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 15 1 2026 01 01 Recovery of renal function and structure following acute kidney injury e27686 e27686 10.34172/jnp.2025.27686 EN Sina Salem Ahim https://orcid.org/0009-0008-2452-434X Ali Emadzadeh https://orcid.org/0009-0000-7311-1164 Shirin Shamsghahfarokhi https://orcid.org/0009-0001-8221-2941 Iman Zafar Asoodeh https://orcid.org/0009-0003-1347-3827 Farid Rahbari https://orcid.org/0009-0009-6966-7405 Hooman Esfahani https://orcid.org/0000-0001-6231-2200 Hamid Rastad https://orcid.org/0009-0003-9322-0394 Rasoul Jafari Arismani https://orcid.org/0000-0001-7440-0507 Journal Article 10.34172/jnp.2025.27686 2025 10 01 2025 12 01 Recovery of renal function and structure following AKI is a complex and multifactorial process involving coordinated tubular epithelial regeneration, resolution of inflammation, restoration of microvascular integrity, and remodeling of the extracellular matrix. Clinical recovery is variable and influenced by injury severity, comorbidities, and therapeutic interventions. Advances in biomarkers and imaging techniques enhance early prediction and monitoring of recovery trajectories. Although no definitive therapies currently exist to reliably speed recovery, promising approaches, including stem cell secretome administration and growth factor modulation, are in development. Long-term consequences of incomplete structural repair highlight the importance of sustained patient follow-up after apparent recovery from AKI.