Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 11 3 2022 07 01 Mixed cryoglobulinemia; a rare presentation of Waldenström macroglobulinemia e15957 e15957 10.34172/jnp.2022.15957 EN Catarina Isabel Ribeiro https://orcid.org/0000-0001-6813-0336 Clara Santos Clara Almeida Teresa Melo David Tente João Carlos Fernandes Journal Article 10.34172/jnp.2022.15957 2020 04 05 2020 07 31 Type II mixed cryoglobulinemia is a systemic disease mediated by immune complexes. Renal involvement is present in almost one third of the cases and the membranoprolifer-ative pattern is the most common histological presentation. In turn, in Waldenström macroglobulinemia, renal impairment is rare, with few cases of associated cryoglobu-linemia being reported. The authors present the case of a patient with type II mixed cry-oglobulinemia associated with Waldenström macroglobulinemia diagnosis.