Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 10 1 2021 01 01 A case of nephrotic syndrome secondary to HIV immune complex kidney disease e09 e09 10.34172/jnp.2021.09 EN Michael Edwards https://orcid.org/0000-0002-9743-8142 Patrick Linden https://orcid.org/0000-0002-2499-2118 Anindya Banerjee https://orcid.org/0000-0003-0396-8749 Journal Article 10.34172/jnp.2021.09 2020 01 08 2020 02 17 HIV immune complex disease of the kidney (HIVICK) is a rare but increasingly well-recognised cause of renal dysfunction and proteinuria in HIV-positive patients. A 56-year-old man with known HIV, diabetes mellitus type 2, liver cirrhosis and previous Hepatitis C virus (HCV) presented with a labile estimated glomerular filtration rate and significant proteinuria. Electron microscopy from a renal biopsy identified capillary wall deposition for IgG, IgM, Kappa, Lambda and focal C1q consistent with membranoproliferative glomerulonephritis (MPGN) and associated immune complex disease. A second opinion of the images confirmed the diagnosis of HIVICK. The increased recognition of HIVICK in HIV patients should prompt further research into the causes and treatment options available.