Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 10 4 2021 10 01 Successful treatment of collapsing focal segmental glomerulosclerosis in a patient e43 e43 10.34172/jnp.2021.43 EN Luísa Helena Pereira https://orcid.org/0000-0002-8031-7299 Ana Cabrita Mário Góis Helena Viana Sandra Sampaio Pedro Leão Neves Journal Article 10.34172/jnp.2021.43 2020 10 02 2020 10 29 Focal segmental glomerulosclerosis (FSGS) is a recognized cause of renal disease worldwide. The collapsing variant is distinct from the others, characterized clinically by a more severe nephrotic syndrome generally resistant to immunosuppressive therapy. It is known that a great number of patients progress to end-stage renal disease. Recognizing this lesion in biopsy is frequently challenging owing to the focal nature of the process which highlights the need for keeping a high index of suspicion for the diagnosis. We report and discuss a case of a non-HIV collapsing FSGS, followed by a complete (unexpected) renal recovery after an oral corticosteroid course.