Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 10 2 2021 04 01 Lung cancer and kidney injury: an updated review e12 e12 10.34172/jnp.2021.12 EN Bhargav Patel https://orcid.org/0000-0001-9019-1151 Mohammad Ebrahimi Kalan https://orcid.org/0000-0001-7709-5392 Maryam Khosravian https://orcid.org/0000-0002-7478-3525 Audrey Tolouian https://orcid.org/0000-0002-9764-8510 Ramin Tolouian https://orcid.org/0000-0003-2242-9310 Mahnaz Aboufazeli https://orcid.org/0000-0002-5868-2695 Masoumeh Asgharpour https://orcid.org/0000-0002-5504-4612 Amirhesam Alirezaei https://orcid.org/0000-0001-9720-6723 Journal Article 10.34172/jnp.2021.12 2020 06 17 2020 08 09 Lung cancer is the leading cause of cancer deaths worldwide, accounting for an estimated 1.8 million deaths. Lung cancer is also the most common primary cancer leading to soft tissue (ST) metastasis. Renal disease may occur as a direct or indirect consequence of the cancer itself (e.g., postrenal obstruction, compression, or infiltration), its treatment (e.g., radiotherapy or chemotherapy), or its related complications (e.g., opportunistic infection). Existing evidence shows that the most frequent primary solid tumor responsible for renal metastasis is pulmonary carcinoma, followed by gastric, breast, soft tissue, and thyroid carcinomas. Chronic kidney disease is a potential risk factor in the survival of patients with lung cancer. In this review, we will discuss causes of kidney injury in relation to lung cancer, potential mechanisms of kidney injury, and treatment options.