Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 11 2 2022 04 01 Membranoproliferative glomerulonephritis in β-thalassemia intermedia; a case report e17186 e17186 10.34172/jnp.2022.17186 EN Maryam Shafiee https://orcid.org/0000-0002-2911-1893 Seyed Alireza Zomorodian https://orcid.org/0000-0003-3298-0325 Seyed Mohammad Owji https://orcid.org/0000-0003-0968-7964 Jamshid Roozbeh Shahroodi https://orcid.org/0000-0002-4268-1727 Mahsa Torabi Jahromi https://orcid.org/0000-0001-9940-1645 Journal Article 10.34172/jnp.2022.17186 2021 01 17 2021 06 14 Introduction: β-thalassemia intermedia reduces the body’s ability to produce adult hemoglobin and causes anemia. In contrast to β-thalassemia major, β-thalassemia intermedia patients do not require lifelong transfusion and are often independent of blood transfusion until young age. Moreover, chronic hypoxia and iron overload may cause tubular and glomerular dysfunction in patients with thalassemia. Case Presentation: We report a 21-year-old female with β-thalassemia intermedia (β-TI) presenting with generalized edema and proteinuria and showed membranoproliferative glomerulonephritis (MPGN) after renal biopsy. Conclusion: The possibility of occurrence of MPGN in patients with thalassemia should be considered. To our knowledge, it is the first case of thalassemia that was reported with MPGN and, more investigation is required to assess the association of thalassemia and MPGN.