Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 13 2 2024 03 10 IgA mediated anti-glomerular basement membrane disease with associated circulating anti-neutrophil cytoplasm antibodies e17371 e17371 10.34172/jnp.2023.17371 EN Patricia Alves https://orcid.org/0000-0001-9859-8618 Mário Góis https://orcid.org/0000-0002-0937-8611 Tiago Pereira Dulce Carvalho Fernando Nolasco https://orcid.org/0000-0002-7089-1975 Journal Article 10.34172/jnp.2023.17371 2022 05 03 2022 12 05 Anti-glomerular basement membrane (anti-GBM) disease is an aggressive small vessel vasculitis usually mediated by IgG autoantibodies. We describe the case of a 73-year-old male with rapidly progressive renal failure that was diagnosed with IgA mediated anti-GBM disease associated with circulating anti-neutrophil cytoplasm antibodies (ANCA), where the diagnosis was established on kidney biopsy by detecting linear deposition of IgA along the GBM on immunofluorescence microscopy. Despite an intensive immunosuppressive regimen with plasmapheresis, steroids and oral cyclophosphamide, the disease progressed to end-stage renal failure and the patient was started on hemodialysis.