Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 12 2 2023 03 18 Determinants of left ventricular diastolic dysfunction in hemodialysis patients e18393 e18393 10.34172/jnp.2022.18393 EN Dorin Dragoş https://orcid.org/0000-0002-0380-6451 Delia Timofte https://orcid.org/0000-0002-0579-6349 Dorin Ionescu https://orcid.org/0000-0003-0411-6732 Andra-Elena Balcangiu-Stroescu https://orcid.org/0000-0003-1467-1983 Maria Iuliana Ghenu https://orcid.org/0000-0002-3945-6617 Ileana Adela Vacaroiu https://orcid.org/0000-0002-7342-6040 Maria Mirabela Manea https://orcid.org/0000-0003-0484-2048 Journal Article 10.34172/jnp.2022.18393 2022 07 04 2022 08 23 Introduction: Chronic kidney disease (CKD) induces changes in the myocardium known to influence morbidity and mortality, most severe in patients with end stage renal disease. Objectives: The working hypothesis was that in patients on chronic hemodialysis the prevalence of left ventricular diastolic dysfunction is correlated with the inflammatory, oxidative, metabolic, nutritional, and atherosclerotic status. Patients and Methods: An observational study was performed on 51 patients (age 59.76 ± 13.24 years) on hemodialysis treatment. Transthoracic cardiac ultrasound was conducted to evaluate LVDD. The burden of cardiac and arterial atherosclerosis was evaluated by cardiac ultrasound (aortic and mitral valve calcifications), vascular ultrasound (carotid and femoral atheroma plaques, common carotid intima-media thickness), and by abdominal radiography (aortic calcification score). Demographic and anthropometric parameters were determined. Blood samples were used to determine laboratory parameters reflecting the inflammatory, oxidative, and metabolic/nutrition status. Results: LVDD is positively correlated with the serum level of C-reactive protein (CRP) (P=0.04), the total antioxidant capacity of the serum (P=0.04), the presence (P=0.022) and number (P=0.04) of femoral plaques, the aortic calcification score (P=0.02), aortic valve stenosis (P=0.037), aortic annulus calcifications (P=0.02) and mitral valve calcifications (P=0.041). After the removal of the main confounder, degenerative aortic stenosis, only the associations with serum total antioxidant capacity (P=0.04) and aortic calcification score (P= 0.02) maintain their statistical significance. Conclusion: LVDD is positively correlated with inflammation and oxidative stress markers and with the severity of aortic calcification.