Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 6 4 2017 10 01 An unusual case of rapidly progressing glomerulonephritis in pregnancy; "triple positivity" or a co incidence? 272 274 10.15171/jnp.2017.44 EN Smita Divyaveer Vaibhav Tiwari Malagouda Patil Chetan Mahajan Tanima Das Bhattacharya Avinandan Banerjee Koushik Bhattacherjee Arpita Raychaudhury Rajendra Pandey Journal Article 10.15171/jnp.2017.44 2017 02 10 2017 05 04 Background: Renal failure in pregnancy is usually due to acute kidney injury and very uncommonly due to rapidly progressing glomerulonephritis (RPGN). We describe here a case of RPGN in the first trimester of pregnancy. Case Presentation: A 26 years old female patient in first trimester of pregnancy presented with RPGN. Investigations revealed dual serological positivity of anti-neutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane antibody (anti-GBM). The biopsy showed crescentic glomerulonephritis with linear with IgG deposition on GBM as well as mesangial IgA deposition. Despite aggressive therapy with cyclophosphamide and plasma exchange she continued to be dialysis dependent and developed end-stage renal disease.