Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 6 4 2017 10 01 The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury 395 398 10.15171/jnp.2017.65 EN Shirin Asgharian Zahra Lorigooini Reza Rafieian Mahmoud Rafieian-Kopaei Soleiman Kheiri Hamid Nasri Journal Article 10.15171/jnp.2017.65 2017 04 10 2017 08 08 Background: Oxygen free radicals are known as one of the causes of kidney injury. Therefore, Berberis vulgaris which has high level of antioxidant activity may be able to prevent this injury by elimination of free radicals. contrast media-induced nephrotoxicity. three groups; Control, contrast media, and contrast media + B. vulgaris extract. After the treatment, histopathological damages to the kidney tissues were comparatively studied. Results: Tissue damage was greater in the contrast media-treated group than the other two groups (P < 0.001). In group treated with B. vulgaris extract, the rate of tissue damage deceased significantly (P < 0.001). nephrotoxicity. This inexpensive and non-toxic medicinal plant might be used as an effective agent for people at risk of contrast-induced acute kidney injury (CI-AKI).