Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 14 1 2025 01 01 Familial Mediterranean fever in two brothers aged seven and five years old e21505 e21505 10.34172/jnp.2024.21505 EN Hedayat Heydarizadeh https://orcid.org/0009-0000-2296-5549 Mohammad Moradi https://orcid.org/0000-0002-7850-2751 Mojtaba Zare https://orcid.org/0000-0003-3346-5018 Samaneh Tahmasebi Ghorabi https://orcid.org/0000-0002-6448-9664 Seyed Hossein Hosseini https://orcid.org/0000-0002-6211-7744 Journal Article 10.34172/jnp.2024.21505 2023 07 01 2024 04 24 Familial Mediterranean fever (FMF) is an inherited disease characterized by fever and intermittent abdominal pain. Due to amyloid deposits in the kidneys and gastrointestinal tract, untreated FMF can lead to severe complications such as end-stage renal disease and malabsorption. The present study reports two brothers aged seven and five years, who presented with fever, abdominal pain, and anorexia. Based on their clinical history and ruling out other possible diagnoses, FMF was definitively diagnosed, and both patients underwent colchicine treatment.