﻿<?xml version="1.0" encoding="UTF-8"?>
<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>Society of Diabetic Nephropathy Prevention</PublisherName>
      <JournalTitle>Journal of Nephropathology</JournalTitle>
      <Issn>2251-8363</Issn>
      <Volume>14</Volume>
      <Issue>1</Issue>
      <PubDate PubStatus="ppublish">
        <Year>2025</Year>
        <Month>01</Month>
        <DAY>01</DAY>
      </PubDate>
    </Journal>
    <ArticleTitle>Antiphospholipid antibody nephropathy; an updated mini-review</ArticleTitle>
    <FirstPage>e21529</FirstPage>
    <LastPage>e21529</LastPage>
    <ELocationID EIdType="doi">10.34172/jnp.2024.21529</ELocationID>
    <Language>EN</Language>
    <AuthorList>
      <Author>
        <FirstName>Mansour</FirstName>
        <LastName>Salesi</LastName>
        <Identifier Source="ORCID">https://orcid.org/0000-0001-7108-6188</Identifier>
      </Author>
      <Author>
        <FirstName>Narges</FirstName>
        <LastName>Ansari</LastName>
        <Identifier Source="ORCID">https://orcid.org/0000-0003-2978-3590</Identifier>
      </Author>
    </AuthorList>
    <PublicationType>Journal Article</PublicationType>
    <ArticleIdList>
      <ArticleId IdType="doi">10.34172/jnp.2024.21529</ArticleId>
    </ArticleIdList>
    <History>
      <PubDate PubStatus="received">
        <Year>2023</Year>
        <Month>10</Month>
        <Day>10</Day>
      </PubDate>
      <PubDate PubStatus="accepted">
        <Year>2023</Year>
        <Month>12</Month>
        <Day>04</Day>
      </PubDate>
    </History>
    <Abstract>Antiphospholipid antibody nephropathy (APLN) is a rare autoimmune disease that affects the kidneys. It is characterized by the deposition of antiphospholipid antibodies (aPL) in the walls of small blood vessels in the kidneys. These antibodies cause inflammation and damage to the blood vessels, leading to various symptoms, including proteinuria, hematuria, hypertension, and renal failure. Several pathological lesions have been identified in APLN, including thrombotic microangiopathy, glomerular endothelial swelling, and fibrinoid necrosis of glomerular capillaries. Thrombotic microangiopathy is the most common lesion and is characterized by the formation of small blood clots in the vessels of the kidney, which can lead to kidney damage and dysfunction. In addition to these lesions, APLN can also cause damage to the tubules and interstitium of the kidney, leading to tubular atrophy, interstitial fibrosis, and chronic kidney disease. These lesions are thought to be caused by the chronic inflammation and immune response associated with APLN.</Abstract>
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        <Param Name="value">Antiphospholipid antibody nephropathy</Param>
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      <Object Type="keyword">
        <Param Name="value">Autoimmune disease</Param>
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      <Object Type="keyword">
        <Param Name="value">Thrombotic microangiopathy</Param>
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      <Object Type="keyword">
        <Param Name="value">Fibrinoid necrosis</Param>
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      <Object Type="keyword">
        <Param Name="value">Renal biopsy</Param>
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      <Object Type="keyword">
        <Param Name="value">Systemic lupus erythematosus</Param>
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  </Article>
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