Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 13 4 2024 08 10 Light chain deposition disease as monoclonal gammopathy of renal significance-a rare disease with scarce therapy; a case report e25550 e25550 10.34172/jnp.2024.25550 EN Fereshteh Saddadi https://orcid.org/0000-0003-4671-2962 Bahareh Marghoob https://orcid.org/0000-0002-1895-2785 Mohamadhasan Fallahkohan https://orcid.org/0000-0002-3200-399X Journal Article 10.34172/jnp.2024.25550 2024 05 09 2024 07 06 The kidneys are one of the main organs which involved in light chain deposition disease (LCDD). The usual renal presentations are renal failure with or without nephrotic range proteinuria and microscopic hematuria. There is not a standard therapy of kidney involvement in this disease which named as monoclonal gammopathy of renal significance (MGRS). The present case is focused on a new therapeutic strategy.