Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 13 4 2024 08 10 Elderly versus young IgA nephropathy; an update on current data e25552 e25552 10.34172/jnp.2024.25552 EN Nadia Pourmohammadi https://orcid.org/0009-0004-4052-2177 Azadeh Khayyat https://orcid.org/0000-0002-1867-1609 Mohammad Ali Esmaeil Pour https://orcid.org/0000-0002-0393-3928 Maryam Ghasemi https://orcid.org/0000-0003-1635-6880 Parisa Kaviani https://orcid.org/0000-0003-0911-7507 Journal Article 10.34172/jnp.2024.25552 2024 05 19 2024 07 05 IgA nephropathy (IgAN) is a common glomerular disease affecting individuals across the age spectrum. However, there are differences in the presentation and prognosis of IgAN between elderly and young adults. Elderly patients with IgAN tend to present with more severe kidney disturbances, worse baseline renal function, and a poorer prognosis compared to young adults. The Oxford classification contributes to the overall prognosis of IgAN in elderly patients by improving prognostic assessment, providing a better determinant of kidney survival, and combining histopathologic findings with clinical features. It offers a more comprehensive approach to understanding the disease course and predicting outcomes in elderly individuals with IgAN. Understanding these differences is a fundamental basis for pinpointing potential therapeutic targets to mitigate age-related renal pathology in IgAN patients.