Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 8 4 2019 10 01 A case of severe nephrotic syndrome caused by isolated CMV glomerulopathy with ganciclovir resistant UL 97 mutation e41 e41 10.15171/jnp.2019.41 EN Ramez R. Sunna Rupinder Sodhi Francis Arden Purvis Rosemary Ouseph David S. Brink Bahar Bastani https://orcid.org/0000-0002-2138-4248 Journal Article 10.15171/jnp.2019.41 2019 06 17 2019 07 29 Introduction: While many cases of cytomegalovirus (CMV) nephropathy have been reported in the literature, isolated CMV glomerulopathy is considered a rare finding. Case Presentation: We report the case of a CMV-negative recipient of kidney allograft from a CMVpositive donor (D+/R-), the recipient subsequently developed severe nephrotic syndrome secondary to biopsy-proven isolated CMV glomerulopathy. Conclusion: The patient developed CMV viremia with ganciclovir resistant UL97 mutation. His treatment course was resistant to recommended dose of intravenous ganciclovir, so therapy was changed to foscarnet with resolution of his viremia and reduction in proteinuria.