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J Nephropathol. 2012;1(1): 23-30. doi: 10.5812/jnp.6
PMID: 24475383        PMCID: PMC3886167

Review Article

Nephro and neurotoxicity of calcineurin inhibitors and mechanisms of rejections: A review on tacrolimus and cyclosporin in organ transplantation

Zahra Tolou-Ghamari 1 *

Cited by CrossRef: 8


1- Fu R, Tajima S, Suetsugu K, Watanabe H, Egashira N, Masuda S. Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation. Acta Pharmacol Sin. 2019;40(2):151 [Crossref]
2- Groll A, Townsend R, Desai A, Azie N, Jones M, Engelhardt M, Schmitt-Hoffman A, Brüggemann R. Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. Transpl Infect Dis. 2017;19(5):e12751 [Crossref]
3- Janikowska G, Kurzeja E, Janikowski M, Strzałka-Mrozik B, Pyka-Pająk A, Janikowski T. The Effect of Cyclosporine A on Dermal Fibroblast Cell - Transcriptomic Analysis of Inflammatory Response Pathway. CPB. 2020;21(12):1213 [Crossref]
4- Shin Y, Lim S, Cui S, Ko E, Chung B, Kim H, Riew T, Lee M, Yang C. Tacrolimus Decreases Cognitive Function by Impairing Hippocampal Synaptic Balance: a Possible Role of Klotho. Mol Neurobiol. 2021;58(11):5954 [Crossref]
5- Fu K, DiNorcia J, Sher L, Velani S, Akhtar S, Kalayjian L, Sanossian N. Predictive Factors of Neurological Complications and One-Month Mortality after Liver Transplantation. Front Neurol. 2014;5 [Crossref]
6- Afzali S, Salehi S, Shahi A, Amirzargar A. B cell modulation strategies in the improvement of transplantation outcomes. Molecular Immunology. 2020;125:140 [Crossref]
7- Mencarelli A, Vacca M, Khameneh H, Acerbi E, Tay A, Zolezzi F, Poidinger M, Mortellaro A. Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway. Front Immunol. 2018;9 [Crossref]
8- Caruso G, Privitera A, Antunes B, Lazzarino G, Lunte S, Aldini G, Caraci F. The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway. Molecules. 2022;27(14):4452 [Crossref]
9- Zhang W, Matsukane R, Egashira N, Tsuchiya Y, Fu R, Yamamoto S, Hirota T, Ieiri I. Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity. Toxicology and Applied Pharmacology. 2022;449:116112 [Crossref]
10- Sendra Gisbert L, Miguel Matas A, Sabater Ortí L, Herrero M, Sabater Olivas L, Montalvá Orón E, Frasson M, Abargues López R, López-Andújar R, García-Granero Ximénez E, Aliño Pellicer S. Efficacy of hydrodynamic interleukin 10 gene transfer in human liver segments with interest in transplantation. Liver Transpl. 2017;23(1):50 [Crossref]
11- Meng L, Feng K, Ren Y. Molecular modelling studies of tricyclic triazinone analogues as potential PKC-θ inhibitors through combined QSAR, molecular docking and molecular dynamics simulations techniques. Journal of the Taiwan Institute of Chemical Engineers. 2018;91:155 [Crossref]
12- Zhang W, Egashira N, Masuda S. Recent Topics on The Mechanisms of Immunosuppressive Therapy-Related Neurotoxicities. IJMS. 2019;20(13):3210 [Crossref]
13- Wilmes D, Coche E, Rodriguez-Villalobos H, Kanaan N. Fungal pneumonia in kidney transplant recipients. Respiratory Medicine. 2021;185:106492 [Crossref]