Logo-jnp
J Nephropathol. 2013;2(1): 20-27. doi: 10.5812/nephropathol.9093
PMID: 24475422        PMCID: PMC3886179

Review Article

Diabetic nephropathy and antioxidants

Majid Tavafi *

Cited by CrossRef: 50


1- Zhang T, Liu C, Ma S, Gao Y, Wang R. Protective Effect and Mechanism of Action of Rosmarinic Acid on Radiation-Induced Parotid Gland Injury in Rats. Dose-Response. 2020;18(1):155932582090778 [Crossref]
2- Samsu N, Bellini M. Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment. BioMed Research International. 2021;2021:1 [Crossref]
3- Ghalishourani S, Farzollahpour F, Shirinbakhshmasoleh M, Kolahdouz S, Ghaedi E, Behrouzian M, Haghighian H, Campbell M, Asbaghi O, Moodi V. Effects of grape products on inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research. 2021;35(9):4898 [Crossref]
4- Deng J, Liu Y, Liu Y, Li W, Nie X. The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy. JIR. 2021;Volume 14:5273 [Crossref]
5- Nazarian-Samani Z, Sewell R, Lorigooini Z, Rafieian-Kopaei M. Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review. Curr Diab Rep. 2018;18(10) [Crossref]
6- Hou Y, Shi Y, Han B, Liu X, Qiao X, Qi Y, Wang L. The antioxidant peptide SS31 prevents oxidative stress, downregulates CD36 and improves renal function in diabetic nephropathy. 2018;33(11):1908 [Crossref]
7- Du Y, Wang L, Qian J, Zhang K, Chai K. Panax notoginseng saponins protect kidney from diabetes by up-regulating silent information regulator 1 and activating antioxidant proteins in rats. Chin J Integr Med. 2016;22(12):910 [Crossref]
8- Hou Y, Li S, Wu M, Wei J, Ren Y, Du C, Wu H, Han C, Duan H, Shi Y. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. American Journal of Physiology-Renal Physiology. 2016;310(6):F547 [Crossref]
9- Saeedi Saravi S, Hasanvand A, Shahkarami K, Dehpour A. The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB/C mice. Pharmaceutical Biology. 2016;54(12):2830 [Crossref]
10- Jaiswal A, Chandra Semwal B, Singh S. A Compressive Review on Novel Molecular Target of Diabetic Nephropathy. RJPT. 2022;:1398 [Crossref]
11- Rahbardar M, Amin B, Mehri S, Mirnajafi-Zadeh S, Hosseinzadeh H. Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects. Phytomedicine. 2018;40:59 [Crossref]
12- Charlton A, Garzarella J, Jandeleit-Dahm K, Jha J. Oxidative Stress and Inflammation in Renal and Cardiovascular Complications of Diabetes. Biology. 2020;10(1):18 [Crossref]
13- Thomas A, Bankar N, Nagore D, Kothapalli L, Chitlange S. Herbal Oils for Treatment of Chronic and Diabetic Wounds: A Systematic Review. CDR. 2022;18(2) [Crossref]
14- Nasri R. Renoprotective effects of metformin. DARU J Pharm Sci. 2013;21(1) [Crossref]
15- Mohamad M, El-Sherbeny E, Bekhet M. The Effect of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes Mellitus. Journal of the American College of Nutrition. 2016;35(5):399 [Crossref]
16- Mehanna O, El Askary A, Al-Shehri S, El-Esawy B. Effect of phosphodiesterase inhibitors on renal functions and oxidant/antioxidant parameters in streptozocin-induced diabetic rats. Archives of Physiology and Biochemistry. 2018;124(5):424 [Crossref]
17- Laustsen C, Nielsen P, Nørlinger T, Qi H, Pedersen U, Bertelsen L, Østergaard J, Flyvbjerg A, Ardenkjær-Larsen J, Palm F, Stødkilde-Jørgensen H. Antioxidant treatment attenuates lactate production in diabetic nephropathy. American Journal of Physiology-Renal Physiology. 2017;312(1):F192 [Crossref]
18- Widyawati T, Syarifah S, Rita Anggraini D, Sari Wahyuni A, Indah Sari M, Feriyawati L. Lawsonia inermis linnaeus leaf ethyl acetate extract evaluation on the kidneys of rats. J Phys: Conf Ser. 2019;1317(1):012091 [Crossref]
19- Antony P, Vijayan R, Zheng J. Identification of Novel Aldose Reductase Inhibitors from Spices: A Molecular Docking and Simulation Study. PLoS ONE. 2015;10(9):e0138186 [Crossref]
20- Feng G, Gao J, Zhang P, Huang J, Huang L, Cheng L, Pu C. Decreased serum extracellular superoxide dismutase activity is associated with albuminuria in Chinese patients with type 2 diabetes mellitus. Acta Diabetol. 2017;54(11):1047 [Crossref]
21- Almogbel E, Rasheed N. Elevated Levels of Protein Carbonylation in Patients With Diabetic Nephropathy: Therapeutic and Diagnostic Prospects. The American Journal of the Medical Sciences. 2019;358(1):26 [Crossref]
22- Kassab B, Hussein H, Mahmoud O, Abdel-Alrahman G. Effects of insulin and metformin on fetal kidney development of streptozotocin-induced gestational diabetic albino rats. Anat Cell Biol. 2019;52(2):161 [Crossref]
23- Wu C, Hung C, Shin Y, Wang C, Huang H. Myrciaria cauliflora extracts attenuate diabetic nephropathy involving the Ras signaling pathway in streptozotocin/nicotinamide mice on a high fat diet. Journal of Food and Drug Analysis. 2016;24(1):136 [Crossref]
24- Li Y, Li X, He K, Li B, Liu K, Qi J, Wang H, Wang Y, Luo W. C‐peptide prevents NF‐κB from recruiting p300 and binding to the inos promoter in diabetic nephropathy . FASEB j. 2018;32(4):2269 [Crossref]
25- Yaribeygi H, Mohammadi M. Evaluation of PPAR-α Agonist effect on Kidney Performance Through Increment of Nitric Oxide During Hyperglycemia-Induced Nephropathy in Rat. Razavi Int J Med. 2016;4(2) [Crossref]
26- Ghasemzadeh Rahbardar M, Amin B, Mehri S, Mirnajafi-Zadeh S, Hosseinzadeh H. Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomedicine & Pharmacotherapy. 2017;86:441 [Crossref]
27- Dong X, An Z, Guo Y, Zhou J, Qin T. Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy. J Huazhong Univ Sci Technol [Med Sci]. 2017;37(1):25 [Crossref]
28- Yaribeygi H, Mohammadi M, Rezaee R, Sahebkar A. Crocin improves renal function by declining Nox‐4, IL‐18, and p53 expression levels in an experimental model of diabetic nephropathy. J of Cellular Biochemistry. 2018;119(7):6080 [Crossref]
29- El Gabbas Z, Bezza K, Laadraoui J, Ait Laaradia M, Kebbou A, Oufquir S, Boukhira A, Aboufatima R, Chait A. Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. Evidence-Based Complementary and Alternative Medicine. 2019;2019:1 [Crossref]
30- Moodi V, Abedi S, Esmaeilpour M, Asbaghi O, Izadi F, Shirinbakhshmasoleh M, Behrouzian M, Shahriari A, Ghaedi E, Miraghajani M. The effect of grapes/grape products on glycemic response: A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research. 2021;35(9):5053 [Crossref]
31- Zhu Q, Li X, Chen H, Jin Q. The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high‑fat diet/streptozotocin‑induced diabetic kidney disease rat model. Exp Ther Med. 2021;22(3) [Crossref]
32- An Z, Dong X, Guo Y, Zhou J, Qin T. Effects and clinical significance of pentoxifylline on the oxidative stress of rats with diabetic nephropathy. J Huazhong Univ Sci Technol [Med Sci]. 2015;35(3):356 [Crossref]
33- Shi Q, Lee D, Féliers D, Abboud H, Bhat M, Gorin Y. Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease. Molecular Metabolism. 2020;36:100968 [Crossref]
34- Kim H, Hwang S, Sung B, Kim Y, Chang Y. Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging. Antioxidants. 2020;9(8):744 [Crossref]
35- Xiong Y, Zhou L. The Signaling of Cellular Senescence in Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity. 2019;2019:1 [Crossref]
36- Rafieian-Kopaei M, Nasri H. The Ameliorative Effect of Zingiber officinale in Diabetic Nephropathy. Iran Red Crescent Med J. 2014;16(5) [Crossref]
37- An L, Zhou M, Marikar F, Hu X, Miao Q, Li P, Chen J. Salvia miltiorrhiza Lipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy through Activation of Nuclear Factor Erythroid 2-Related Factor 2. Am J Chin Med. 2017;45(07):1441 [Crossref]
38- Rafieian-Kopaei M, Nasri H. Comment on: Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats. Med Sci Monit Basic Res. 2013;19:208 [Crossref]
39- Østergaard J, Cooper M, Jandeleit-Dahm K. Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease. J Nephrol. 2020;33(5):917 [Crossref]
40- Gomes I, Porto M, Santos M, Campagnaro B, Pereira T, Meyrelles S, Vasquez E. Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy. Lipids Health Dis. 2014;13(1) [Crossref]
41- Dua T, Joardar S, Chakraborty P, Bhowmick S, Saha A, De Feo V, Dewanjee S. Myricitrin, a Glycosyloxyflavone in Myrica esculenta Bark Ameliorates Diabetic Nephropathy via Improving Glycemic Status, Reducing Oxidative Stress, and Suppressing Inflammation. Molecules. 2021;26(2):258 [Crossref]
42- Ebrahimi Z, Nasli-Esfahani E, Nadjarzade A, Mozaffari-khosravi H. Effect of symbiotic supplementation on glycemic control, lipid profiles and microalbuminuria in patients with non-obese type 2 diabetes: a randomized, double-blind, clinical trial. J Diabetes Metab Disord. 2017;16(1) [Crossref]
43- Лактіонова О, Коляда К, Фоменко Р, Лахно О. ДОДАТКОВІ ПАТОФІЗІОЛОГІЧНІ ШЛЯХИ РОЗВИТКУ ТА ПРОГРЕСУВАННЯ ДІАБЕТИЧНОЇ НЕФРОПАТІЇ. GoS. 2022;(16):518 [Crossref]
44- Nasri H, Rafieian-Kopaei M. Garlic and Kidney Injury Protection. Shiraz E-Med J. 2013;14(4) [Crossref]
45- Ahangarpour A, Oroojan A, Khorsandi L, Shabani R, Mojaddami S. Preventive effects of betulinic acid on streptozotocinnicotinamide induced diabetic nephropathy in male mouse. J Nephropathol. 2016;5(4):128 [Crossref]
46- Bondor C, Potra A, Moldovan D, Rusu C, Ciorba Pop M, Muresan A, Vladutiu D, Kacso I. Relationship of adiponectin to markers of oxidative stress in type 2 diabetic patients: influence of incipient diabetes-associated kidney disease. Int Urol Nephrol. 2015;47(7):1173 [Crossref]
47- Sherif I. Secoisolariciresinol diglucoside in high-fat diet and streptozotocin-induced diabetic nephropathy in rats: a possible renoprotective effect. J Physiol Biochem. 2014;70(4):961 [Crossref]
48- Asbaghi O, Moodi V, Neisi A, Shirinbakhshmasoleh M, Abedi S, Oskouie F, Eslampour E, Ghaedi E, Miraghajani M. The effect of almond intake on glycemic control: A systematic review and dose–response meta‐analysis of randomized controlled trials . Phytotherapy Research. 2022;36(1):395 [Crossref]
49- Rafieian-Kopaei M. In Vitro Evaluation of Antioxidant Properties of Ten Iranian Medicinal Plants. Iran Red Crescent Med J. 2014;16(6) [Crossref]
50- Ulubay M, Alkan I, Yurt K, Kaplan S. The protective effect of curcumin on the diabetic rat kidney: A stereological, electron microscopic and immunohistochemical study. Acta Histochemica. 2020;122(2):151486 [Crossref]
51- Nasri H. Re Metformin revisited: A critical review of the benefit–risk balance in at-risk patients with type 2 diabetes. Diabetes & Metabolism. 2013;39(4):375 [Crossref]
52- Rafieian Kopaei M, Baradaran A. Protective Effects of Metformin on Renal Tubular Cells. Iran Red Crescent Med J. 2014;16(9) [Crossref]
53- Alqasim A, Nour Eldin E, Hammadi S, Esheba G. Comparing the renoprotective effects of the antioxidants melatonin, vitamin D and vitamin E in diabetic rats. Journal of Taibah University Medical Sciences. 2020;15(5):351 [Crossref]
54- Shahrani M, Asgari A, Abedi Gheshlaghi Z, Parvin N, Nasri P, Shirzad H, Rafieian Kopaei M. Effect of Kelussia odoratissima Mozaffarian on Lipid and Glucose Profile. Shiraz E-Med J. 2015;16(8) [Crossref]
55- Yaribeygi H, Simental‐Mendía L, Butler A, Sahebkar A. Protective effects of plant‐derived natural products on renal complications. Journal Cellular Physiology. 2019;234(8):12161 [Crossref]
56- Golla U. Emergence of nutraceuticals as the alternative medications for pharmaceuticals. IJCAM. 2018;11(3) [Crossref]
57- Sutariya B, Saraf M. Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway. Journal of Ethnopharmacology. 2017;198:432 [Crossref]
58- Dare A, Channa M, Nadar A. L-ergothioneine; a potential adjuvant in the management of diabetic nephropathy. Pharmacological Research - Modern Chinese Medicine. 2022;2:100033 [Crossref]
59- Yonekura Y, Fujii H, Nakai K, Kono K, Goto S, Shinohara M, Nishi S. Anti-oxidative effect of theβ-blocker carvedilol on diabetic nephropathy in non-obese type 2 diabetic rats. Clin Exp Pharmacol Physiol. 2015;42(9):972 [Crossref]
60- ALTamimi J, AlFaris N, Alshammari G, Alagal R, Aljabryn D, Aldera H, Alrfaei B, Alkhateeb M, Yahya M. Ellagic acid protects against diabetic nephropathy in rats by regulating the transcription and activity of Nrf2. Journal of Functional Foods. 2021;79:104397 [Crossref]
61- Baradaran A. Commentary on: effect of vitamin D on insulin resistance and anthropometric parameters in type 2 diabetes; a randomized double-blind clinical trial. DARU J Pharm Sci. 2013;21(1) [Crossref]
62- Albeladi F, Mostafa M, Zayed M, Atta H. Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus. IJGM. 2022;Volume 15:5919 [Crossref]