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J Nephropathol. 2016;5(4): 128-133. doi: 10.15171/jnp.2016.24
PMID: 27921024        PMCID: PMC5125059

Original Article

Preventive effects of betulinic acid on streptozotocinnicotinamide induced diabetic nephropathy in male mouse

Akram Ahangarpour 1, Ali Akbar Oroojan 2 * , Layasadat Khorsandi 3, Razieh Shabani 4, Shahnaz Mojaddami 4

Cited by CrossRef: 23


1- Farkhondeh T, Samarghandian S, Azimi-Nezhad M, Hozeifi S. The Hepato-protective Effects of Portulaca oleracea L. extract: Review. CDDT. 2019;16(2):122 [Crossref]
2- Sayah K, Mrabti H, Belarj B, Kichou F, Cherrah Y, El Abbes Faouzi M. Evaluation of antidiabetic effect of Cistus salviifolius L. (Cistaceae) in streptozotocin-nicotinamide induced diabetic mice. 2021;32(2):121 [Crossref]
3- Prakash B, Surendran A, Radhakrishnan Chandraprabha V, Pettamanna A, Raveendran Nair H. Betulinic acid, natural pentacyclic triterpenoid prevents arsenic-induced nephrotoxicity in male Wistar rats. Comp Clin Pathol. 2018;27(1):37 [Crossref]
4- Berköz M, Çiftçi O. Boswellic Acid and Betulinic Acid Pre-treatments Can Prevent the Nephrotoxicity Caused by Cyclophosphamide Induction. Dokl Biochem Biophys. 2024;517(1):115 [Crossref]
5- Ansari P, Akther S, Hannan J, Seidel V, Nujat N, Abdel-Wahab Y. Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus. Molecules. 2022;27(13):4278 [Crossref]
6- Guo L, Jiang B, Li D, Xiao X. Nephroprotective Effect of Adropinin Against Streptozotocin-Induced Diabetic Nephropathy in Rats: Inflammatory Mechanism and YAP/TAZ Factor. DDDT. 2021;Volume 15:589 [Crossref]
7- Lou H, Li H, Zhang S, Lu H, Chen Q. A Review on Preparation of Betulinic Acid and Its Biological Activities. Molecules. 2021;26(18):5583 [Crossref]
8- Huang K, Guan S, Lin W, Wu C, Sheu M, Chiang C, Liu S. Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury. Cells. 2019;8(7):660 [Crossref]
9- Lee H, Lee I, Kang K, Park S, Kwon T, Lee D, Wang X. An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study. Evidence-Based Complementary and Alternative Medicine. 2020;2020(1) [Crossref]
10- Wang X, Yuan Z, Zhu L, Yi X, Ou Z, Li R, Tan Z, Pozniak B, Obminska-Mrukowicz B, Wu J, Yi J. Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice. Pharmacological Reports. 2019;71(5):929 [Crossref]
11- Chen H, Li R, Zhao F, Luan L, Han T, Li Z. Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans. Front Nutr. 2022;9 [Crossref]
12- Lee H, Lee J, Han J. Betulinic acid improves TNF- α -induced insulin resistance by inhibiting negative regulator of insulin signalling and inflammation-activated protein kinase in 3T3-L1 adipocytes . Archives of Physiology and Biochemistry. 2024;130(4):452 [Crossref]
13- Antar S, Abd-Elsalam M, Abdo W, Abdeen A, Abdo M, Fericean L, Raslan N, Ibrahim S, Sharif A, Elalfy A, Nasr H, Zaid A, Atia R, Atwa A, Gebba M, Alzokaky A. Modulatory Role of Autophagy in Metformin Therapeutic Activity toward Doxorubicin-Induced Nephrotoxicity. Toxics. 2023;11(3):273 [Crossref]
14- Farkhondeh T, Samarghandian S. The therapeutic effects of Portulaca oleracea L. in hepatogastric disorders. Gastroenterología y Hepatología. 2019;42(2):127 [Crossref]
15- S, Gupta A. Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF-α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats. CDDT. 2024;21(1) [Crossref]
16- Birgani G, Ahangarpour A, Khorsandi L, Moghaddam H. Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model. Braz J Pharm Sci. 2018;54(2) [Crossref]
17- Bellampalli S, Ji Y, Moutal A, Cai S, Wijeratne E, Gandini M, Yu J, Chefdeville A, Dorame A, Chew L, Madura C, Luo S, Molnar G, Khanna M, Streicher J, Zamponi G, Gunatilaka A, Khanna R. Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury–associated peripheral sensory neuropathy via block of N- and T-type calcium channels. Pain. 2019;160(1):117 [Crossref]
18- Basist P, Parveen B, Zahiruddin S, Gautam G, Parveen R, Khan M, Krishnan A, Shahid M, Ahmad S. Potential nephroprotective phytochemicals: Mechanism and future prospects. Journal of Ethnopharmacology. 2022;283:114743 [Crossref]
19- Pottathil S, Nain P, Morsy M, Kaur J, Al-Dhubiab B, Jaiswal S, Nair A. Mechanisms of Antidiabetic Activity of Methanolic Extract of Punica granatum Leaves in Nicotinamide/Streptozotocin-Induced Type 2 Diabetes in Rats. Plants. 2020;9(11):1609 [Crossref]
20- Farkhondeh T, Samarghandian S. The therapeutic effects of Portulaca oleracea L. in hepatogastric disorders. Gastroenterología y Hepatología (English Edition). 2019;42(2):127 [Crossref]
21- Amiri S, Dastghaib S, Ahmadi M, Mehrbod P, Khadem F, Behrouj H, Aghanoori M, Machaj F, Ghamsari M, Rosik J, Hudecki A, Afkhami A, Hashemi M, Los M, Mokarram P, Madrakian T, Ghavami S. Betulin and its derivatives as novel compounds with different pharmacological effects. Biotechnology Advances. 2020;38:107409 [Crossref]
22- Wang Q, Wang J, Li N, Liu J, Zhou J, Zhuang P, Chen H. A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications. Molecules. 2022;27(2):444 [Crossref]