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J Nephropathol. 2017;6(3): 163-167. doi: 10.15171/jnp.2017.28
PMID: 28975096        PMCID: PMC5607978

Original Article

Time course of cisplatin-induced nephrotoxicity and hepatotoxicity

Zahra Pezeshki 1, Atoosa Khosravi 1, Mina Nekuei 1, Samaneh Khoshnood 1, Elnaz Zandi 1, Marjan Eslamian 1, Ardeshir Talebi 1,2, Seyyed Nasir-e-din Emami 3, Mehdi Nematbakhsh 1,4,5 *

Cited by CrossRef: 31


1- Gong S, Feng Y, Zeng Y, Zhang H, Pan M, He F, Wu R, Chen J, Lu J, Zhang S, Yuan S, Chen X. Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice. J Transl Med. 2021;19(1) [Crossref]
2- Okon E, Luszczki J, Kukula-Koch W, Halasa M, Jarzab A, Khurelbat D, Stepulak A, Wawruszak A. Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin. IJMS. 2020;21(8):2848 [Crossref]
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5- Farkhondeh T, Samarghandian S. The therapeutic effects of Portulaca oleracea L. in hepatogastric disorders. Gastroenterología y Hepatología (English Edition). 2019;42(2):127 [Crossref]
6- Kann S, Shaughnessey E, Zhang X, Charest J, Vedula E. Steady-state monitoring of oxygen in a high-throughput organ-on-chip platform enables rapid and non-invasive assessment of drug-induced nephrotoxicity. Analyst. 2023;148(14):3204 [Crossref]
7- Tchounwou P, Dasari S, Noubissi F, Ray P, Kumar S. Advances in Our Understanding of the Molecular Mechanisms of Action of Cisplatin in Cancer Therapy. JEP. 2021;Volume 13:303 [Crossref]
8- Yilmaz A, Dizman F, Akyildiz K, Mataraci Karakas S, Mercantepe T, Uydu H, Tumkaya L, Ozturk K. The Hepatoprotective Effects of Camellia sinensis on Cisplatin-Induced Acute Liver Injury. Life. 2024;14(9):1077 [Crossref]
9- Un H, Ugan R, Kose D, Bayir Y, Cadirci E, Selli J, Halici Z. A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity. European Journal of Pharmacology. 2020;880:173168 [Crossref]
10- Farkhondeh T, Samarghandian S. The therapeutic effects of Portulaca oleracea L. in hepatogastric disorders. Gastroenterología y Hepatología. 2019;42(2):127 [Crossref]
11- Xiang Y, Ji M, Wu L, Lv L, Liang Q, Deng R, Deng Z, Liu X, Ren L, Feng X, He J. Rosmarinic Acid Prevents Cisplatin-Induced Liver and Kidney Injury by Inhibiting Inflammatory Responses and Enhancing Total Antioxidant Capacity, Thereby Activating the Nrf2 Signaling Pathway. Molecules. 2022;27(22):7815 [Crossref]
12- A.A. Aly H, G. Eid B. Cisplatin induced testicular damage through mitochondria mediated apoptosis, inflammation and oxidative stress in rats: impact of resveratrol. Endocr J. 2020;67(9):969 [Crossref]
13- Evaluation of Biochemical and Pathological Parameters at Different Doses of Cisplatin in Experimental Animal Model: Toxicological Study on an Antineoplastic Drug. MJHR. 2022;26(1) [Crossref]
14- Ozkul O, Ozkul B, Erdogan M, Erbas O. Ameliorating Effect of Propofol on Cisplatin-Induced Liver and Kidney Damage in Rats. International J of Pharmacology. 2022;18(8):1623 [Crossref]
15- Mercantepe F, Mercantepe T, Topcu A, Yılmaz A, Tumkaya L. Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury. Naunyn-Schmiedeberg's Arch Pharmacol. 2018;391(9):915 [Crossref]
16- Farkhondeh T, Samarghandian S, Azimi-Nezhad M, Hozeifi S. The Hepato-protective Effects of Portulaca oleracea L. extract: Review. CDDT. 2019;16(2):122 [Crossref]
17- Chen C, Xu C, Li T, Lu S, Luo F, Wang H. Novel NHC-coordinated ruthenium(II) arene complexes achieve synergistic efficacy as safe and effective anticancer therapeutics. European Journal of Medicinal Chemistry. 2020;203:112605 [Crossref]
18- Umar H, Wahab H, Attiq A, Amjad M, Bukhari S, Ahmad W. Platinum-based targeted chemotherapies and reversal of cisplatin resistance in non-small cell lung cancer (NSCLC). Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2024;828:111856 [Crossref]
19- Taguchi H, Sumi D, Uemura A, Matsumoto K, Fujishiro H. Cisplatin caused highly delayed cytotoxicity in the immortalized cells derived from S3 segment of mouse kidney proximal tubules. Toxicology and Applied Pharmacology. 2025;494:117171 [Crossref]
20- Aydemir L, Iplik E, Ertugrul B, Kasarci G, Atas M, Ulusan M, Ergen A, Cakmakoglu B. Levofloxacin might be safe to use for OSCC patients. Med Oncol. 2021;38(8) [Crossref]
21- Chandra Shill M, El‐Nashar H, Prova Mollick P, Nath Acharyya R, Afrin S, Hossain H, Halder S, Torequl Islam M, Bhuia M, Reza H, El‐Shazly M, Mubarak M. Longevity Spinach (Gynura procumbens) Ameliorated Oxidative Stress and Inflammatory Mediators in Cisplatin‐Induced Organ Dysfunction in Rats: Comprehensive in vivo and in silico Studies. Chemistry & Biodiversity. 2024;21(5) [Crossref]
22- BİRİNCİ H, ŞEN HALICIOĞLU B, ÖZTATLICI M, YÜNCÜ M. Sisplatinin Neden Olduğu Nefrotoksisite Ve Ultrastrüktürel Hasar Üzerine Kurkuminin Koruyucu Etkisi. 2021;8(4):598 [Crossref]
23- Abdel-Bakky M, Aldakhili A, Ali H, Babiker A, Alhowail A, Mohammed S. Evaluation of Cisplatin-Induced Acute Renal Failure Amelioration Using Fondaparinux and Alteplase. Pharmaceuticals. 2023;16(7):910 [Crossref]
24- Anbar H, Shehab N, El-Rouby N, Ansari M, Chenoth H, Majeed M, Naeem K, Hersi F, Omar H. Upadacitinib protects against cisplatin-induced renal and hepatic dysfunction without impairing its anticancer activity. European Journal of Pharmaceutical Sciences. 2022;172:106149 [Crossref]
25- Narayanankutty A, Illam S, Rao V, Shehabudheen S, Raghavamenon A. Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil. Drug and Chemical Toxicology. 2022;45(3):1373 [Crossref]
26- Bilgic Y, Akbulut S, Aksungur Z, Erdemli M, Ozhan O, Parlakpinar H, Vardi N, Turkoz Y. Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity. Exp Ther Med. 2018; [Crossref]
27- Jeon J, Lee S, Kim H, Kang H, Youn H, Jo S, Youn B, Kim H. Revisiting Platinum-Based Anticancer Drugs to Overcome Gliomas. IJMS. 2021;22(10):5111 [Crossref]
28- Attia A, Matta C, ElMazoudy R, Khalifa H. Cisplatin-induced neurotoxicity in cerebellar cortex of male mice involves oxidative stress and histopathology. JoBAZ. 2021;82(1) [Crossref]
29- Khairnar S, Mahajan U, Patil K, Patel H, Shinde S, Goyal S, Belemkar S, Ojha S, Patil C. Disulfiram and Its Copper Chelate Attenuate Cisplatin-Induced Acute Nephrotoxicity in Rats Via Reduction of Oxidative Stress and Inflammation. Biol Trace Elem Res. 2020;193(1):174 [Crossref]
30- Moazamiyanfar R, Rezaei S, AliAshrafzadeh H, Rastegar-Pouyani N, Jafarzadeh E, Mouludi K, Khodamoradi E, Zhaleh M, Taeb S, Najafi M. Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives. CPD. 2023;29(22):1713 [Crossref]
31- Xu M, Zhang L, Lin L, Qiang Z, Liu W, Yang J. Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1. J Biomed Res. 2023;37(6):431 [Crossref]
32- Carneiro T, Araújo R, Vojtek M, Gonçalves-Monteiro S, Diniz C, Batista de Carvalho A, Marques M, Gil A. Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent. Metabolites. 2021;11(2):114 [Crossref]
33- Fatima S, Suhail N, Alrashed M, Wasi S, Aljaser F, AlSubki R, Alsharidah A, Banu N. Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin‐induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosis. J Biochem & Molecular Tox. 2021;35(4) [Crossref]