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J Nephropathol. 2018;7(1): 37-42. doi: 10.15171/jnp.2018.11

Original Article

Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through activation of AMPK signaling pathway

Amin Hasanvand 1,2,3,4, Hossein Amini-Khoei 5, Samane Jahanabadi 6, Mohammad-Reza Hadian 7, Alireza Abdollahi 8, Seyed Mohammad Tavangar 9, Shahram jtemaei Mehr 1,2,3 * , Ahmad Reza Dehpour 1,2,3 *

Cited by CrossRef: 9


1- Rashwan A, El-Beltagy M, Saleh S, Ibrahim I. Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption. Beni-Suef Univ J Basic Appl Sci. 2019;8(1) [Crossref]
2- Abdelkader N, Elbaset M, Moustafa P, Ibrahim S. Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling. Arch Pharm Res. 2022;45(7):475 [Crossref]
3- Hasanvand A. The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases. Inflammopharmacol. 2022;30(3):775 [Crossref]
4- Juszczak F, Pierre L, Decarnoncle M, Jadot I, Martin B, Botton O, Caron N, Dehairs J, Swinnen J, Declèves A. Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis. Biol Sex Differ. 2023;14(1) [Crossref]
5- Juszczak F, Caron N, Mathew A, Declèves A. Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease. IJMS. 2020;21(21):7994 [Crossref]
6- Saleh H, Salama M, Hussein R. Polyethylene glycol capped gold nanoparticles ameliorate renal ischemia–reperfusion injury in diabetic mice through AMPK-Nrf2 signaling pathway. Environ Sci Pollut Res. 2022;29(51):77884 [Crossref]
7- Kokate D, Marathe P. Evaluation of Effect of Montelukast in the Model of Streptozotocin Induced Diabetic Nephropathy in Rats. 2024;28(1):47 [Crossref]
8- AlTamimi J, AlFaris N, Alshammari G, Alagal R, Aljabryn D, Yahya M. The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK. Nutrients. 2023;15(7):1660 [Crossref]
9- Malaekeh-Nikouei A, Shokri-Naei S, Karbasforoushan S, Bahari H, Baradaran Rahimi V, Heidari R, Askari V. Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins. Biomedicine & Pharmacotherapy. 2023;165:115263 [Crossref]