A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model?

Mehdi Nematbakhsh; Farzaneh Ashrafi; Zahra Pezeshki; Zahra Fatahi; Fariborz Kianpoor; Mohammad-Hossein Sanei; Ardeshir Talebi

doi:10.5812/nephropathol.8122

J Nephropathol. 2012;1(3): 190-193.
doi: 10.5812/nephropathol.8122

PMID: 24475415
PMCID: PMC3886150
Scopus ID: 84874747005

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Brief Report

A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model?

Mehdi Nematbakhsh ^1,2,3^*, Farzaneh Ashrafi ^1,4, Zahra Pezeshki ¹, Zahra Fatahi ⁵, Fariborz Kianpoor ¹, Mohammad-Hossein Sanei ⁶, Ardeshir Talebi ⁶

¹ Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran.
² Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Clinical Pathologist, Isfahan, Iran.
⁶ Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.

*Corresponding Author: *Corresponding author:Prof. Mehdi Nematbakhsh. Water & Electrolytes Research Center and Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. Telephone: +98311-6688597, fax: +98311-6688597 , Email: nematbakhsh@med.mui.ac.ir

Abstract

Background: Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity.

Objectives: To found, which of the toxicities is the first side effect of CP.

Materials and Methods: we conducted a pilot research on 12 adult male Wistar rats.

Results: One week after CP administration, the induced toxicity was observed clearly in kidney tissue. The only abnormality that observed in testis tissue was very small degree of hyaline casts. However, no damage and other abnormality were detected in the liver tissue.

Conclusions: According to these findings, in clinic, first special attention must be made on kidneys during chemotherapy with CP. However, the duration of experiment is suggested to be extended to obtain hepatoxicity or testicular toxicity model in experimental animal in laboratories. Moreover, different dose of CP should be used to study the first side effect in animal model.

Keywords: Nephrotoxicity, Hepatoxicity, Cisplatin, Toxicity

Implication for health policy/practice/research/medical education:

Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with various major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. In clinic, first special attention must be made on kidneys during chemotherapy with CP.

Please cite this paper as: Nematbakhsh M, Ashrafi F, Pezeshki Z , Fatahi Z , Kianpoor F, Sanei MH, Talebi A:A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model. J Nephropathology.2012; 1(3): 190-193. DOI: 10.5812/nephropathol.8122

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