A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model?

Mehdi Nematbakhsh; Farzaneh Ashrafi; Zahra Pezeshki; Zahra Fatahi; Fariborz Kianpoor; Mohammad-Hossein Sanei; Ardeshir Talebi

doi:10.5812/nephropathol.8122

J Nephropathol. 2012;1(3): 190-193.
doi: 10.5812/nephropathol.8122

PMID: 24475415
PMCID: PMC3886150
Scopus ID: 84874747005

Abstract View: 6641

PDF Download: 3108

Brief Report

A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model?

Mehdi Nematbakhsh ^1,2,3^*, Farzaneh Ashrafi ^1,4, Zahra Pezeshki ¹, Zahra Fatahi ⁵, Fariborz Kianpoor ¹, Mohammad-Hossein Sanei ⁶, Ardeshir Talebi ⁶

¹ Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran.
² Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Clinical Pathologist, Isfahan, Iran.
⁶ Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.

*Corresponding Author: *Corresponding author:Prof. Mehdi Nematbakhsh. Water & Electrolytes Research Center and Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. Telephone: +98311-6688597, fax: +98311-6688597 , Email: nematbakhsh@med.mui.ac.ir

Abstract

Background: Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity.

Objectives: To found, which of the toxicities is the first side effect of CP.

Materials and Methods: we conducted a pilot research on 12 adult male Wistar rats.

Results: One week after CP administration, the induced toxicity was observed clearly in kidney tissue. The only abnormality that observed in testis tissue was very small degree of hyaline casts. However, no damage and other abnormality were detected in the liver tissue.

Conclusions: According to these findings, in clinic, first special attention must be made on kidneys during chemotherapy with CP. However, the duration of experiment is suggested to be extended to obtain hepatoxicity or testicular toxicity model in experimental animal in laboratories. Moreover, different dose of CP should be used to study the first side effect in animal model.

Keywords: Nephrotoxicity, Hepatoxicity, Cisplatin, Toxicity

Implication for health policy/practice/research/medical education:

Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with various major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. In clinic, first special attention must be made on kidneys during chemotherapy with CP.

Please cite this paper as: Nematbakhsh M, Ashrafi F, Pezeshki Z , Fatahi Z , Kianpoor F, Sanei MH, Talebi A:A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model. J Nephropathology.2012; 1(3): 190-193. DOI: 10.5812/nephropathol.8122

First Name

Last Name

Email Address

Comments

Security code

Generate New Image

Type the code from the image

Abstract View: 6642

years	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sep	Oct	Nov	Dec
2024	67	61	36	29	76	32	25	45	43	55	13
2023	47	49	38	37	5	63	51	59	72	84	49	65
2022	80	116	112	94	58	74	64	45	28	48	41	72
2021	48	47	54	45	69	62	53	71	76	123	78	64
2020	114	35	83	75	81	55	74	63	67	78	40	46
2019	59	72	55	97	54	62	65	97	105	104	40	69
2018	115	140	145	129	113	115	58	64	64	57	48	68
2017		9	118	108	94	93	102	116	111	108	104	150

PDF Download: 3108

years	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sep	Oct	Nov	Dec
2024	15	4	7	11	10	9	4	4	14	23	3
2023	27	21	14	17		20	18	28	9	15	12	9
2022	26	28	24	18	14	21	17	23	16	14	19	20
2021	40	37	48	38	37	29	34	43	37	40	38	26
2020	46	16	25	37	24	25	42	22	24	25	32	37
2019	40	40	44	44	36	32	38	42	40	46	21	31
2018	61	98	91	80	77	86	47	21	31	30	32	43
2017		8	66	62	65	53	60	65	61	63	56	62