Implication for health policy/practice/research/medical education:
Hyperoxaluria often coexists with recurrent pyelonephritis which may be caused by the destruction of the gut microbiota. It would be logical to assume the formation of a so-called “vicious circle”. On the one hand, the development of dysbiosis and intestinal barrier dysfunction, mediated by the constant use of antibiotics, are the main sources of urinary tract infection; while they lead to impaired oxalate transport and acquired hyperoxaluria. In turn, calcium oxalate deposition in the proximal renal tubules causes chronic inflammation and might be an independent risk factor for pyelonephritis recurrences. Further studies are needed to clarify the mechanism of this interaction.
Please cite this paper as: Stepanova N. Hyperoxaluria; a risk factor or a consequence of recurrent pyelonephritis? J Nephropathol. 2021;10(4):e36. DOI: 10.34172/jnp.2021.36.