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J Nephropathol. 2022;11(2): e17341.
doi: 10.34172/jnp.2022.17341
  Abstract View: 93
  PDF Download: 64

Original Article

Ameliorative impact of ezetimibe on gentamicin-induced kidney damage; A histopathological perspective study

Elham Emami 1 ORCID logo, Ali Hasanpour Dehkordi 2 ORCID logo, Ahmadreza Maghsoudi 3* ORCID logo, Hamid Nasri 3,4,5* ORCID logo, Alireza Vahedi 6 ORCID logo

1 Pediatric Nephrology Research Center (PNRC), Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Emam Hosein hospital, Tehran, Iran
2 Social Determinants of Health, Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Pathology, Nickan Research Institute, Isfahan, Iran
5 Eurasian Nephropathology Society (ENPS), Moscow, Russia
6 Breast Cancer Research Center, Motemed Cancer Institute, Tehran, Iran
*Corresponding Authors: *Corresponding authors: Ahmadreza Maghsoudi, Email: ahmaghsoudi@med.mui.ac.ir, , Email: dr_maghsoudi_md@ yahoo.com; *Corresponding authors: Hamid Nasri, Email: , Email: hamidnasri@med.mui.ac.ir

Abstract

Introduction: Gentamicin, despite its beneficial effects, has significant nephrotoxic effects that are observed in 20% of the patients. Ezetimibe is recognized as an inhibitor of cholesterol absorption.

Objectives: The present study aimed to investigate the histopathological effects of ezetimibe on gentamicin-induced kidney damage.

Material and Methods: Twenty male Wistar rats were randomly divided into five groups and treated as the following; group 1 (normal group), group 2 [gentamicin group, daily 80 mg/kg, intraperitoneal (i.p.) for seven days], group 3-5 (gentamicin 80 + ezetimibe at doses of 2.5, 12.5, and 37.5 mg/kg, respectively). Kidney sections were examined for histopathological parameters including vacuolization of the tubular renal cells, degeneration, necrosis, flattening of the tubular cells and debris in the tubular lumen.

Results: Gentamicin injection significantly induced histopathological alterations (P< 0.05). Ezetimibe therapy significantly decreased the levels of vacuolization, degeneration, necrosis, flattening of the tubular cells and debris in the nephrotoxic rats (P< 0.05).

Conclusion: The results illustrated that treatment with ezetimibe can improve kidney damage caused by gentamicin injection.



Implication for health policy/practice/research/medical education:

In an experimental study, we found that treatment with ezetimibe can improve kidney damage caused by gentamicin injection.

Please cite this paper as: Emami E, Hasanpour Dehkordi A, Maghsoudi A, Nasri H, Vahedi A. Ameliorative impact of ezetimibe on gentamicininducedkidney damage; A histopathological perspective. J Nephropathol. 2022;11(2):e17341. DOI: 10.34172/jnp.2022.17341.


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Submitted: 11 Sep 2021
Accepted: 20 Dec 2021
ePublished: 10 Jan 2022
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