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J Nephropathol. 2017;6(3): 225-230.
doi: 10.15171/jnp.2017.37
PMID: 28975105
PMCID: PMC5607987
Scopus ID: 85019897671
  Abstract View: 3655
  PDF Download: 2185

Original Article

Acute interstitial nephritis in the south of Iran; an observational study

Zohre Khodamoradi 1, Maryam Pakfetrat 2, Simin Torabinezhad 3, Mohammad Mahdi Sagheb 2*

1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Nephrology, Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
*Corresponding Author: *Corresponding author: Mohammad Mahdi Sagheb, , Email: saghebf@gmail.com

Abstract

Background: Acute interstitial nephritis (AIN) is an emerging cause of acute kidney injury
(AKI) during the recent years.

Objectives: There is no data about prevalence, causes, clinical manifestation and outcomes
of AIN in our region. Hence, in this study we aimed to find the prevalence of AIN and
describe the causes, clinical presentation, and the outcome of AIN in the native kidney
biopsies.

Patients and Methods: We reviewed 934 native kidney biopsies from 2006 to 2014 and
collected the data of patients with the diagnosis of AIN including medical history, clinical
findings, para-clinical data, pathologic findings, treatment and outcomes.

Results: Prevalence of AIN in our center during 2006 to 2014 was 2.5% of all renal biopsies.
The common cause of AIN in our study was drugs. Of those patients admitted to hospital
due to AIN, 17 patients (70.8%) received corticosteroid, five of them (29.4%) received
pulse of corticosteroid, and 12 patients (70.6%) received oral drug. Around, 54.2% of the
patients had hemodialysis during admission. Eight patients had received both dialysis and
corticosteroid. Two of them (8.3%) remained on dialysis and 8 (33.3%) developed chronic
kidney disease, but 14 (58.3%) patients recovered.

Conclusions: The prevalence of AIN in our study is comparable to other studies and we
found the great impact of medications on development of AIN.


Implication for health policy/practice/research/medical education:

 
Acute kidney injury (AKI) is an increasing problem across the world. Acute interstitial nephritis (AIN) is a main cause of
AKI during the recent years and also it has an increasing prevalence. AIN is a major health problem and is associated with
morbidity and mortality. Our findings showed that prevalence of AIN in our center during 2006 to 2014 was close to that
in western countries. Nowadays etiology of AIN has changed and drugs became an emerging cause. Antibiotics and proton
pump inhibitors (PPI) are the major culprit in drug- induced AIN. Although there are controversies regarding efficacy of
corticosteroids for the treatment of AIN, corticosteroids are used in AIN.

Please cite this paper as: Khodamoradi Z, Pakfetrat M, Torabinezhad S, Sagheb MM. Acute interstitial nephritis in the south of
Iran; an observational study. J Nephropathol. 2017;6(3):225-230. DOI: 10.15171/jnp.2017.37.

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ePublished: 20 Apr 2017
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